ReviewReviews in endocrine & metabolic disorders2008
Clinical and molecular genetics of acromegaly: MEN1, Carney complex, McCune-Albright syndrome, familial acromegaly and genetic defects in sporadic tumors.
Review in Reviews in endocrine & metabolic disorders, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 96 citations in OpenAlex.
- Multiple endocrine neoplasia type 1 combined with thyroid neoplasm: A case report and review of literatures.World journal of clinical cases · 2022Article
- Is Routine Screening of Young Asymptomatic MEN1 Patients Necessary?World journal of surgery · 2017Article
- AIP mutations in young patients with acromegaly and the Tampico Giant: the Mexican experience.Endocrine · 2016Article
- A giant? Think of genetics: growth hormone-producing adenomas in the young are almost always the result of genetic defects.Endocrine · 2015Article
- Carney complex and McCune Albright syndrome: an overview of clinical manifestations and human molecular genetics.Molecular and cellular endocrinology · 2014Review
- mTOR is frequently active in GH-secreting pituitary adenomas without influencing their morphopathological features.Endocrine pathology · 2013Article
- Acrodysostosis syndromes.BoneKEy reports · 2012Review
- Clinical and genetic aspects of familial isolated pituitary adenomas.Clinics (Sao Paulo, Brazil) · 2012Review
- Pituitary tumors in patients with MEN1 syndrome.Clinics (Sao Paulo, Brazil) · 2012Review
- Sporadic and genetic forms of paediatric somatotropinoma: a retrospective analysis of seven cases and a review of the literature.Orphanet journal of rare diseases · 2011Review
- McCune-Albright syndrome: surgical and therapeutic challenges in GH-secreting pituitary adenomas.Journal of neuro-oncology · 2011Article
- Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families.Human mutation · 2010Article
- An Intronic mutation is associated with prolactinoma in a young boy, decreased penetrance in his large family, and variable effects on MEN1 mRNA and protein.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2009Article
- Familial pituitary tumor syndromes.Nature reviews. Endocrinology · 2009Review
- Article
- Advances in the Diagnosis, Treatment, and Molecular Genetics of Pituitary Adenomas in Childhood.US endocrinology · 2009Article
- Review
- Pituitary tumors in childhood: update of diagnosis, treatment and molecular genetics.Expert review of neurotherapeutics · 2008Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Pituitary tumors are among the most common neoplasms in man; they account for approximately 15% of all primary intracranial lesions (Jagannathan et al., Neurosurg Focus, 19:E4, 2005). Although almost never malignant and rarely clinically expressed, pituitary tumors may cause significant morbidity in affected patients. First, given the critical location of the gland, large tumors may lead to mass effects, and, second, proliferation of hormone-secreting pituitary cells leads to endocrine syndromes. Acromegaly results from oversecretion of growth hormone (GH) by the proliferating somatotrophs. Despite the significant efforts made over the last decade, still little is known about the genetic causes of common pituitary tumors and even less is applied from this knowledge therapeutically. In this review, we present an update on the genetic syndromes associated with pituitary adenomas and discuss the related genetic defects. We next review findings on sporadic, non-genetic, pituitary tumors with an emphasis on pathways and animal models of pituitary disease. In conclusion, we attempt to present an overall, integrative approach to the human molecular genetics of both familiar and sporadic pituitary tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.