ArticleGenes and immunity2008
SNPs upstream of the minimal promoter control IL-2 expression and are candidates for the autoimmune disease-susceptibility locus Aod2/Idd3/Eae3.
Article in Genes and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity.Frontiers in cellular and infection microbiology · 2014Review
- Polymorphic variant at the IL2 region is associated with type 1 diabetes and may affect serum levels of interleukin-2.Molecular biology reports · 2013Article
- Regulatory T cells and vasectomy.Journal of reproductive immunology · 2013Article
- Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8⁺ T cells.Clinical and experimental immunology · 2013Article
- Genetic analysis of type 1 diabetes: embryonic stem cells as new tools to unlock biological mechanisms in type 1 diabetes.The review of diabetic studies : RDS · 2012Review
- Genetics of experimental allergic encephalomyelitis supports the role of T helper cells in multiple sclerosis pathogenesis.Annals of neurology · 2011Article
- Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The postnatal maternal environment affects autoimmune disease susceptibility in A/J mice.Cellular immunology · 2010Article
- Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- A single nucleotide polymorphism in Tyk2 controls susceptibility to experimental allergic encephalomyelitis.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.Diabetes · 2009Article
- The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice.Journal of clinical immunology · 2008Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
IL-2, a T-cell growth and differentiation factor, plays an important role in immune homeostasis. Previously, we identified IL2 as a candidate for Aod2, a quantitative trait locus (QTL) controlling susceptibility to autoimmune ovarian dysgenesis (AOD) induced by day 3 neonatal thymectomy. Here, we report the identification of single-nucleotide polymorphisms (SNPs) in a region upstream of the minimal IL2 promoter (-2.8 kb to -300 bp), which distinguish AOD-susceptible A/J and AOD-resistant C57BL/6J (B6/J) mice. Six of the SNPs (-1010 C --> T, -962 C --> T, -926/-925 Delta Delta --> AC, -921 T --> C, -914 T --> C and -674 G --> A) contribute to the enhanced transcriptional activity of the extended B6/J promoter relative to A/J. Importantly, the -1010 SNP resides within a canonical AP-1-binding motif with the C --> T transition at this site abrogating AP-1 binding. Moreover, these SNPs segregate with differential production of IL-2 by CD4(+) T cells as well as susceptibility alleles at Idd3 and Eae3, QTL controlling insulin-dependent diabetes mellitus and experimental allergic encephalomyelitis. These are the first SNPs identified within the extended murine IL2 promoter that control differential IL-2 transcription in CD4(+) T cells, and, as such, they are not only candidates for Aod2, but are also candidates for a shared autoimmune disease-susceptibility locus underlying Idd3 and Eae3.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.