ArticleGenome research2008
No effect of recombination on the efficacy of natural selection in primates.
Article in Genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 58 citations in OpenAlex.
- Causes and consequences of a complex recombinational landscape in the antGenome research · 2024Article
- Increased Positive Selection in Highly Recombining Genes Does not Necessarily Reflect an Evolutionary Advantage of Recombination.Molecular biology and evolution · 2024Article
- The role of recombination dynamics in shaping signatures of direct and indirect selection across theProceedings. Biological sciences · 2024Article
- Extreme variation in recombination rate and genetic diversity along the Sylvioidea neo-sex chromosome.Molecular ecology · 2022Article
- Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome.PLoS genetics · 2021Article
- Accumulation of Deleterious Mutations in Landlocked Threespine Stickleback Populations.Genome biology and evolution · 2020Article
- Impact of Mutation Rate and Selection at Linked Sites on DNA Variation across the Genomes of Humans and Other Homininae.Genome biology and evolution · 2020Article
- Exploiting selection at linked sites to infer the rate and strength of adaptation.Nature ecology & evolution · 2019Article
- Determinants of the Efficacy of Natural Selection on Coding and Noncoding Variability in Two Passerine Species.Genome biology and evolution · 2017Article
- Genetic Effect of Chemotherapy Exposure in Children of Testicular Cancer Survivors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Article
- Experimental evolution of recombination and crossover interference in Drosophila caused by directional selection for stress-related traits.BMC biology · 2015Article
- Article
- Highly variable recombinational landscape modulates efficacy of natural selection in birds.Genome biology and evolution · 2014Article
- Recombination rates and genomic shuffling in human and chimpanzee--a new twist in the chromosomal speciation theory.Molecular biology and evolution · 2013Article
- Genomic signatures of selection at linked sites: unifying the disparity among species.Nature reviews. Genetics · 2013Review
- Weak selection and protein evolution.Genetics · 2012Review
- Recombination modulates how selection affects linked sites in Drosophila.PLoS biology · 2012Article
- Article
- Effective population size and the efficacy of selection on the X chromosomes of two closely related Drosophila species.Genome biology and evolution · 2011Article
- Genomic determinants of protein evolution and polymorphism in Arabidopsis.Genome biology and evolution · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Population genetic theory suggests that natural selection should be less effective in regions of low recombination, potentially leading to differences in rates of adaptation among recombination environments. To date, this prediction has mainly been tested in Drosophila, with somewhat conflicting results. We investigated the association between human recombination rates and adaptation in primates, by considering rates of protein evolution (measured by d(N)/d(S)) between human, chimpanzee, and rhesus macaque. We found no correlation between either broad- or fine-scale rates of recombination and rates of protein evolution, once GC content is taken into account. Moreover, genes in regions of very low recombination, which are expected to show the most pronounced reduction in the efficacy of selection, do not evolve at a different rate than other genes. Thus, there is no evidence for differences in the efficacy of selection across recombinational environments. An interesting implication is that indirect selection for recombination modifiers has probably been a weak force in primate evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.