ArticleMolecular biology and evolution2008
Nonadaptive explanations for signatures of partial selective sweeps in Drosophila.
Article in Molecular biology and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- A Large Panel of Drosophila simulans Reveals an Abundance of Common Variants.Genome biology and evolution · 2018Article
- Shifting fitness landscapes in response to altered environments.Evolution; international journal of organic evolution · 2013Article
- Patterns of selection and polymorphism of innate immunity genes in bumblebees (Hymenoptera: Apidae).Genetica · 2012Article
- Haplotype structure and expression divergence at the Drosophila cellular immune gene eater.Molecular biology and evolution · 2010Article
- Patterns and processes of genome-wide divergence between North American and African Drosophila melanogaster.Genetics · 2010Article
- Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila.PLoS genetics · 2010Article
- The evolution of transposable elements in natural populations of self-fertilizing Arabidopsis thaliana and its outcrossing relative Arabidopsis lyrata.BMC evolutionary biology · 2010Article
- Review
- A recent adaptive transposable element insertion near highly conserved developmental loci in Drosophila melanogaster.Molecular biology and evolution · 2009Article
- Pervasive natural selection in the Drosophila genome?PLoS genetics · 2009Article
- Signals of recent positive selection in a worldwide sample of human populations.Genome research · 2009Article
- Inferring the strength of selection in Drosophila under complex demographic models.Molecular biology and evolution · 2009Article
- Pervasive hitchhiking at coding and regulatory sites in humans.PLoS genetics · 2009Article
- High rate of recent transposable element-induced adaptation in Drosophila melanogaster.PLoS biology · 2008Article
- High genetic differentiation between the M and S molecular forms of Anopheles gambiae in Africa.PloS one · 2008Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
A beneficial mutation that has nearly but not yet fixed in a population produces a characteristic haplotype configuration, called a partial selective sweep. Whether nonadaptive processes might generate similar haplotype configurations has not been extensively explored. Here, we consider 5 population genetic data sets taken from regions flanking high-frequency transposable elements in North American strains of Drosophila melanogaster, each of which appears to be consistent with the expectations of a partial selective sweep. We use coalescent simulations to explore whether incorporation of the species' demographic history, purifying selection against the element, or suppression of recombination caused by the element could generate putatively adaptive haplotype configurations. Whereas most of the data sets would be rejected as nonneutral under the standard neutral null model, only the data set for which there is strong external evidence in support of an adaptive transposition appears to be nonneutral under the more complex null model and in particular when demography is taken into account. High-frequency, derived mutations from a recently bottlenecked population, such as we study here, are of great interest to evolutionary genetics in the context of scans for adaptive events; we discuss the broader implications of our findings in this context.
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