ArticleJournal of clinical microbiology2008
Evaluation of new variable-number tandem-repeat systems for typing Mycobacterium tuberculosis with Beijing genotype isolates from Beijing, China.
Article in Journal of clinical microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Exploring the "Latin American Mediterranean" family and the RDBMC microbiology · 2019Article
- Genotyping and drug-resistance epidemiology ofInternational journal of clinical and experimental pathology · 2017Article
- Genotyping ofInternational journal of bacteriology · 2016Article
- Optimal Combination of VNTR Typing for Discrimination of Isolated Mycobacterium tuberculosis in Korea.Tuberculosis and respiratory diseases · 2014Article
- Suitability of IS6110-RFLP and MIRU-VNTR for differentiating spoligotyped drug-resistant mycobacterium tuberculosis clinical isolates from Sichuan in China.BioMed research international · 2014Article
- Development of a hierarchical variable-number tandem repeat typing scheme for Mycobacterium tuberculosis in China.PloS one · 2014Article
- Genotypic diversity analysis of Mycobacterium tuberculosis strains collected from Beijing in 2009, using spoligotyping and VNTR typing.PloS one · 2014Article
- First insight into the genotypic diversity of clinical Mycobacterium tuberculosis isolates from Gansu Province, China.PloS one · 2014Article
- Comparison between RFLP and MIRU-VNTR genotyping of Mycobacterium tuberculosis strains isolated in Stockholm 2009 to 2011.PloS one · 2014Article
- Spoligotyping and drug resistance patterns of Mycobacterium tuberculosis isolates from five provinces of Iran.MicrobiologyOpen · 2013Article
- Genotyping and clinical characteristics of multidrug and extensively drug-resistant tuberculosis in a tertiary care tuberculosis hospital in China.BMC infectious diseases · 2013Article
- Insights into the origin, emergence, and current spread of a successful Russian clone of Mycobacterium tuberculosis.Clinical microbiology reviews · 2013Review
- Molecular epidemiology of Mycobacterium tuberculosis complex in Singapore, 2006-2012.PloS one · 2013Article
- Genetic diversity of Mycobacterium tuberculosis isolates from Beijing, China assessed by Spoligotyping, LSPs and VNTR profiles.BMC infectious diseases · 2012Article
- Combination of single nucleotide polymorphism and variable-number tandem repeats for genotyping a homogenous population of Mycobacterium tuberculosis Beijing strains in China.Journal of clinical microbiology · 2012Article
- Genetic diversity and transmission characteristics of Beijing family strains of Mycobacterium tuberculosis in Peru.PloS one · 2012Article
- Article
- Genetic diversity of Mycobacterium tuberculosis isolates from Tibetans in Tibet, China.PloS one · 2012Article
- Mycobacterial interspersed repetitive-unit locus PCR amplification and Beijing strains of Mycobacterium tuberculosis.Journal of clinical microbiology · 2011Article
- Molecular typing of Mycobacterium tuberculosis isolates circulating in Jiangsu province, China.BMC infectious diseases · 2011Article
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7 authors.
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Abstract
The newly proposed variable-number tandem-repeat (VNTR) typing system, which includes a basic 15-locus set and a high-resolution 24-locus set (P. Supply et al., J. Clin. Microbiol. 44:4498-4510, 2006), demonstrated a high power for the discrimination of Mycobacterium tuberculosis isolates collected worldwide. To evaluate its ability to differentiate the Beijing genotype strains from the Beijing area in China, 72 isolates with typical Beijing or Beijing-like spacer oligonucleotide typing profiles were subjected to typing with the VNTR system (24 loci) and typing by restriction fragment polymorphism analysis with IS6110 (IS6110-RFLP). Compared to the "old" 12-locus VNTR typing method, use of the 15- and 24-locus systems had a dramatically improved power to discriminate the Beijing genotype strains. A subtle difference in the Hunter-Gaston discriminatory index (HGI) between the 15-locus and the 24-locus systems resulted from only one locus, Mtub29. However, the VNTR-based clusters could be further differentiated by IS6110-RFLP (HGI by IS6110 RFLP, 0.999), although in one case an IS6110 cluster was subdivided by the 15-locus VNTR system. In this sense, use of the newly proposed 15-locus VNTR system along with the Mtub29 locus can serve as a first-line typing method for the epidemiological study of M. tuberculosis isolates in Beijing, while secondary typing of clustered strains by IS6110-RFLP is still required.
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