ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Distribution, amplification, and summation of cyclic nucleotide sensitivities within single olfactory sensory cilia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Constancy of olfactory cilia in rodents.Chemical senses · 2025Article
- Olfactory cilia, regulation and control of olfaction.Physiological reports · 2024Review
- Segregation of Ca2+ signaling in olfactory signal transduction.The Journal of general physiology · 2023Article
- The cyclic AMP signaling pathway in the rodent main olfactory system.Cell and tissue research · 2021Review
- Second messenger molecules have a limited spread in olfactory cilia.The Journal of general physiology · 2018Article
- NaV1.5 sodium channel window currents contribute to spontaneous firing in olfactory sensory neurons.Journal of neurophysiology · 2014Article
- 2,4,6-trichloroanisole is a potent suppressor of olfactory signal transduction.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Cell- and subunit-specific mechanisms of CNG channel ciliary trafficking and localization in C. elegans.Journal of cell science · 2013Article
- Hyperpolarisation-activated cyclic nucleotide-gated channels regulate the spontaneous firing rate of olfactory receptor neurons and affect glomerular formation in mice.The Journal of physiology · 2013Article
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- Signaling by olfactory receptor neurons near threshold.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Cellular and molecular Ca2+ microdomains in olfactory cilia support low signaling amplification of odor transduction.The European journal of neuroscience · 2010Article
- The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Somatostatin signaling in neuronal cilia is critical for object recognition memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Mechanism of olfactory masking in the sensory cilia.The Journal of general physiology · 2009Article
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- Sensory signaling-dependent remodeling of olfactory cilia architecture in C. elegans.Developmental cell · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Submicron local cAMP elevation was used to map the distribution of transduction channels in single olfactory cilia. After the fine fluorescent visualization of the cilium with the laser-scanning confocal microscope, the intraciliary cAMP was jumped locally with the laser beam that photolyzes cytoplasmic caged compounds. Simultaneously, cells' responses were obtained with the whole-cell patch clamp. Responses were observed anywhere within the cilia, showing the broad distribution of transduction channels. For odor detection, such distribution would be useful for expanding the available responding area to increase the quantum efficiency. Also, the stimulus onto only 1 microm region induced >100 pA response operated by >700-2300 channels, although only 1 pA is sufficient for olfactory cells to generate action potentials. The large local response indicates a presence of strong amplification achieved with a high-density distribution of the transduction channels for the local ciliary excitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.