ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Regulation of respiratory and vocal motor pools in the isolated brain of Xenopus laevis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Convergent and divergent neural circuit architectures that support acoustic communication.Frontiers in neural circuits · 2022Pooled it
- The Medullary Audio-Vocal Network in the Toad Bombina orientalis.The Journal of comparative neurology · 2025Article
- Gekko gecko as a model organism for understanding aspects of laryngeal vocal evolution.The Journal of experimental biology · 2024Article
- Article
- Characterization of laryngeal motor neuron properties in the American bullfrog, Lithobates catesbieanus.Respiratory physiology & neurobiology · 2021Article
- Generation, Coordination, and Evolution of Neural Circuits for Vocal Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- Inspiring song: The role of respiratory circuitry in the evolution of vertebrate vocal behavior.Developmental neurobiology · 2020Review
- Feedback to the future: motor neuron contributions to central pattern generator function.The Journal of experimental biology · 2019Review
- Premotor Neuron Divergence Reflects Vocal Evolution.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Insight into the neuroendocrine basis of signal evolution: a case study in foot-flagging frogs.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Review
- Motor Neurons Tune Premotor Activity in a Vertebrate Central Pattern Generator.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Evolution of vocal patterns: tuning hindbrain circuits during species divergence.The Journal of experimental biology · 2017Article
- Probing forebrain to hindbrain circuit functions in Xenopus.Genesis (New York, N.Y. : 2000) · 2017Review
- Harnessing vocal patterns for social communication.Current opinion in neurobiology · 2014Review
- Efficacy of tricaine methanesulfonate (MS-222) as an anesthetic agent for blocking sensory-motor responses in Xenopus laevis tadpoles.PloS one · 2014Article
- The Xenopus amygdala mediates socially appropriate vocal communication signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Distinct neural and neuromuscular strategies underlie independent evolution of simplified advertisement calls.Proceedings. Biological sciences · 2013Article
- Coding rate and duration of vocalizations of the frog, Xenopus laevis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- A neuroendocrine basis for the hierarchical control of frog courtship vocalizations.Frontiers in neuroendocrinology · 2011Review
- Vocal pathway degradation in gonadectomized Xenopus laevis adults.Journal of neurophysiology · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The aquatic frog Xenopus laevis uses a complex vocal repertoire during mating and male-male interactions. Calls are produced without breathing, allowing the frogs to vocalize for long periods underwater. The Xenopus vocal organ, the larynx, is innervated by neurons in cranial motor nucleus (n.) IX-X, which contains both vocal (laryngeal) and respiratory (glottal) motor neurons. The primary descending input to n.IX-X comes from the pretrigeminal nucleus of the dorsal tegmental area of the medulla (DTAM), located in the rostral hindbrain. We wanted to characterize premotor inputs to respiratory and vocal motor neurons and to determine what mechanisms might be involved in regulating two temporally distinct rhythmic behaviors: breathing and calling. Using isolated brain and larynx preparations, we recorded extracellular activity from the laryngeal nerve and muscles and intracellular activity in laryngeal and glottal motor neurons. Spontaneous nerve activities mimicking respiratory and vocal patterns were observed. DTAM projection neurons (DTAM(IX-X) neurons) provide direct input to glottal and laryngeal motor neurons. Electrical stimulation produced short-latency coordinated activity in the laryngeal nerve. DTAM(IX-X) neurons provide excitatory monosynaptic inputs to laryngeal motor neurons and mixed excitatory and inhibitory inputs to glottal motor neurons. DTAM stimulation also produced a delayed burst of glottal motor neuron activity. Together, our data suggest that neurons in DTAM produce vocal motor output by directly activating laryngeal motor neurons and that DTAM may coordinate vocal and respiratory motor activity.
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