ArticleMolecular biology of the cell2008
Different effects of Tetrahymena IFT172 domains on anterograde and retrograde intraflagellar transport.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- Primary cilia-associated protein IFT172 in ciliopathies.Frontiers in cell and developmental biology · 2023Review
- Establishing a High-Throughput Locomotion Tracking Method for Multiple Biological Assessments inCells · 2022Article
- STORM imaging reveals the spatial arrangement of transition zone components and IFT particles at the ciliary base in Tetrahymena.Scientific reports · 2021Article
- Intraflagellar transport trains and motors: Insights from structure.Seminars in cell & developmental biology · 2020Review
- Structural insights into the architecture and assembly of eukaryotic flagella.Microbial cell (Graz, Austria) · 2020Review
- Murine germ cell-specific disruption of Ift172 causes defects in spermiogenesis and male fertility.Reproduction (Cambridge, England) · 2020Article
- Cilia drive developmental plasticity and are essential for efficient prey detection in predatory nematodes.Proceedings. Biological sciences · 2019Article
- Primary Cilium in Cancer Hallmarks.International journal of molecular sciences · 2019Review
- Composition, structure and function of the eukaryotic flagellum distal tip.Essays in biochemistry · 2018Review
- Membrane association and remodeling by intraflagellar transport protein IFT172.Nature communications · 2018Article
- Emerging mechanisms of dynein transport in the cytoplasm versus the cilium.Biochemical Society transactions · 2018Review
- The Intraflagellar Transport Machinery.Cold Spring Harbor perspectives in biology · 2016Review
- Two classes of short intraflagellar transport train with different 3D structures are present in Chlamydomonas flagella.Journal of cell science · 2016Article
- Identification of a novel mutation confirms the implication of IFT172 (BBS20) in Bardet-Biedl syndrome.Journal of human genetics · 2016Article
- Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin-binding IFT-B2 complex.The EMBO journal · 2016Article
- The CSC proteins FAP61 and FAP251 build the basal substructures of radial spoke 3 in cilia.Molecular biology of the cell · 2015Article
- Ciliopathies: the trafficking connection.Traffic (Copenhagen, Denmark) · 2014Review
- ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.The EMBO journal · 2014Article
- Intraflagellar transport gene expression associated with short cilia in smoking and COPD.PloS one · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Intraflagellar transport (IFT) particles are multiprotein complexes that move bidirectionally along the cilium/flagellum. The Tetrahymena IFT172 gene encodes a protein with an N-terminal WD domain (WDD) and a C-terminal repeat domain (RPD). Epitope-tagged Ift172p localized to the basal body and in cilia along the axoneme, and IFT172 knockout cells lost cilia and motility. Using serial deletion constructs to rescue the knockout cells, we found that neither the WDD nor the RPD alone is sufficient to assemble cilia. Ift172p containing only the WDD or the RPD failed to enter cilia. Constructs with a partial truncation of the RPD still rescued although cilia were assembled less efficiently, indicating that the WDD and a part of the RPD are sufficient for anterograde transport. Partial truncation of the RPD caused the accumulation of truncated Ift172p itself and of Ift88p at ciliary tips, suggesting that IFT turnaround or retrograde transport was affected. These results implicate different regions of Ift172p in different steps of the IFT process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.