ArticleBiophysical journal2008
Exploring the control circuit of cell migration by mathematical modeling.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Three-component contour dynamics model to simulate and analyze amoeboid cell motility in two dimensions.PloS one · 2024Article
- Crawling, waving, inch worming, dilating, and pivoting mechanics of migrating cells: Lessons from Ken Jacobson.Biophysical journal · 2023Review
- Coupling cell shape and velocity leads to oscillation and circling in keratocyte galvanotaxis.Biophysical journal · 2023Article
- Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling.Biophysical journal · 2022Article
- Purinoreceptors and ectonucleotidases control ATP-induced calcium waveforms and calcium-dependent responses in microglia: Roles of P2 receptors and CD39 in ATP-stimulated microglia.Frontiers in physiology · 2022Article
- Neighbor-enhanced diffusivity in dense, cohesive cell populations.PLoS computational biology · 2021Article
- Traction force microscopy by deep learning.Biophysical journal · 2021Article
- Tools for computational analysis of moving boundary problems in cellular mechanobiology.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Bridging from single to collective cell migration: A review of models and links to experiments.PLoS computational biology · 2020Review
- Phosphatidylinositol 4-kinase III beta regulates cell shape, migration, and focal adhesion number.Molecular biology of the cell · 2020Article
- OrgDyn: feature- and model-based characterization of spatial and temporal organoid dynamics.Bioinformatics (Oxford, England) · 2020Article
- Centrosome defines the rear of cells during mesenchymal migration.Molecular biology of the cell · 2017Article
- A free-boundary model of a motile cell explains turning behavior.PLoS computational biology · 2017Article
- Excitable Signal Transduction Networks in Directed Cell Migration.Annual review of cell and developmental biology · 2017Review
- Virtual cardiac monolayers for electrical wave propagation.Scientific reports · 2017Article
- Enhanced Directional Migration of Cancer Stem Cells in 3D Aligned Collagen Matrices.Biophysical journal · 2017Article
- Visualizing Morphogenesis with the Processing Programming Language.The Journal of biocommunication · 2017Article
- Article
- Crawling and Gliding: A Computational Model for Shape-Driven Cell Migration.PLoS computational biology · 2015Article
- Parameter identification problems in the modelling of cell motility.Journal of mathematical biology · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We have developed a top-down, rule-based mathematical model to explore the basic principles that coordinate mechanochemical events during animal cell migration, particularly the local-stimulation-global-inhibition model suggested originally for chemotaxis. Cells were modeled as a shape machine that protrudes or retracts in response to a combination of local protrusion and global retraction signals. Using an optimization algorithm to identify parameters that generate specific shapes and migration patterns, we show that the mechanism of local stimulation global inhibition can readily account for the behavior of Dictyostelium under a large collection of conditions. Within this collection, some parameters showed strong correlation, indicating that a normal phenotype may be maintained by complementation among functional modules. In addition, comparison of parameters for control and nocodazole-treated Dictyostelium identified the most prominent effect of microtubules as regulating the rates of retraction and protrusion signal decay, and the extent of global inhibition. Other changes in parameters can lead to profound transformations from amoeboid cells into cells mimicking keratocytes, neurons, or fibroblasts. Thus, a simple circuit of local stimulation-global inhibition can account for a wide range of cell behaviors. A similar top-down approach may be applied to other complex problems and combined with molecular manipulations to define specific protein functions.
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