ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2008
Diagnostic performance of an expert system for interpretation of 99mTc MAG3 scans in suspected renal obstruction.
Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Guidance document for structured reporting of diuresis renography.Seminars in nuclear medicine · 2012Guideline
- A 7% decrease in the differential renal uptake of MAG3 implies a loss in renal function.Urology · 2010Trial
- P3LS: Point Process Partial Least Squares.Biometrics · 2026Article
- Association between urinary biomarkers MMP-7/TIMP-2 and reduced renal function in children with ureteropelvic junction obstruction.PloS one · 2022Article
- Identification of Signature Genes and Construction of an Artificial Neural Network Model of Prostate Cancer.Journal of healthcare engineering · 2022Article
- A Bayesian Latent Class Model to Predict Kidney Obstruction in the Absence of Gold Standard.Journal of the American Statistical Association · 2020Article
- SNMMI Procedure Standard/EANM Practice Guideline for Diuretic Renal Scintigraphy in Adults With Suspected Upper Urinary Tract Obstruction 1.0.Seminars in nuclear medicine · 2018Article
- Urinary Proteomics Yield Pathological Insights for Ureteropelvic Junction Obstruction.Molecular & cellular proteomics : MCP · 2016Article
- Radionuclides in nephrourology, Part 2: pitfalls and diagnostic applications.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2014Review
- Computer-assisted diagnosis in renal nuclear medicine: rationale, methodology, and interpretative criteria for diuretic renography.Seminars in nuclear medicine · 2014Review
- Development of a relational database to capture and merge clinical history with the quantitative results of radionuclide renography.Journal of nuclear medicine technology · 2012Article
- iRENEX: a clinically informed decision support system for the interpretation of ⁹⁹mTc-MAG3 scans to detect renal obstruction.European journal of nuclear medicine and molecular imaging · 2012Article
- Key variables for interpreting 99mTc-mercaptoacetyltriglycine diuretic scans: development and validation of a predictive model.AJR. American journal of roentgenology · 2011Article
- Computer-aided diagnosis of renal obstruction: utility of log-linear modeling versus standard ROC and kappa analysis.EJNMMI research · 2011Article
- Automated patient motion detection and correction in dynamic renal scintigraphy.Journal of nuclear medicine technology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledThe purpose of the study was to compare diuresis renography scan interpretation generated by a renal expert system with the consensus interpretation of 3 expert readers.
methodsThe expert system was evaluated in 95 randomly selected furosemide-augmented patient studies (185 kidneys) obtained for suspected obstruction; there were 55 males and 40 females with a mean age +/- SD of 58.6 +/- 16.5 y. Each subject had a baseline (99m)Tc-mercaptoacetyltriglycine ((99m)Tc-MAG3) scan followed by furosemide administration and a separate 20-min acquisition. Quantitative parameters were automatically extracted from baseline and furosemide acquisitions and forwarded to the expert system for analysis. Three experts, unaware of clinical information, independently graded each kidney as obstructed/probably obstructed, equivocal, and probably nonobstructed/nonobstructed; experts resolved differences by a consensus reading. These 3 expert categories were compared with the obstructed, equivocal, and nonobstructed interpretations provided by the expert system. Agreement was assessed using weighted kappa, and the predictive accuracy of the expert system compared with expert readers was assessed by the area under receiver-operating-characteristic (ROC curve) curves.
resultsThe expert system agreed with the consensus reading in 84% (101/120) of nonobstructed kidneys, in 92% (33/36) of obstructed kidneys, and in 45% (13/29) of equivocal kidneys. The weighted kappa between the expert system and the consensus reading was 0.72 and was comparable with the weighted kappa between experts. There was no significant difference in the areas under the ROC curves when the expert system was compared with each expert using the other 2 experts as the gold standard.
conclusionThe renal expert system showed good agreement with the expert interpretation and could be a useful educational and decision support tool to assist physicians in the diagnosis of renal obstruction. To better mirror the clinical setting, algorithms to incorporate clinical data must be designed, implemented, and tested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.