ArticleBMC evolutionary biology2008
The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors.
Article in BMC evolutionary biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed.
- Morphological characterization, mitochondrial genome assembly, and phylogenetic reconstruction of Branchiostoma malayanum within Branchiostomatidae.Scientific reports · 2025Article
- G-protein-coupled receptor diversity and evolution in the closest living relatives of metazoa.eLife · 2025Article
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- Article
- Evolution, Expression and Functional Analysis of CXCR3 in Neuronal and Cardiovascular Diseases: A Narrative Review.Frontiers in cell and developmental biology · 2022Review
- The role of GPR56/ADGRG1 in health and disease.Biomedical journal · 2021Review
- An Ancient Adenosine Receptor Gains Olfactory Function in Bony Vertebrates.Genome biology and evolution · 2021Article
- Evolution of thymopoietic microenvironments.Open biology · 2021Review
- The evolutionary origins of the vertebrate olfactory system.Open biology · 2020Review
- Holothurians have a reduced GPCR and odorant receptor-like repertoire compared to other echinoderms.Scientific reports · 2020Article
- New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts.Frontiers in endocrinology · 2020Review
- Revisiting the classification of adhesion GPCRs.Annals of the New York Academy of Sciences · 2019Article
- Phylogenetic Reclassification of Vertebrate Melatonin Receptors To Include Mel1d.G3 (Bethesda, Md.) · 2019Article
- Innate immunity in the simplest animals - placozoans.BMC genomics · 2019Article
- The role of GPCRs in bone diseases and dysfunctions.Bone research · 2019Review
- A role for the CXCR4-CXCL12 axis in the little skate, Leucoraja erinacea.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- The evolution of neuropeptide signalling: insights from echinoderms.Briefings in functional genomics · 2017Review
- Methuselah/Methuselah-like G protein-coupled receptors constitute an ancient metazoan gene family.Scientific reports · 2016Article
- Functional Pairing of Class B1 Ligand-GPCR in Cephalochordate Provides Evidence of the Origin of PTH and PACAP/Glucagon Receptor Family.Molecular biology and evolution · 2015Article
- International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.Pharmacological reviews · 2015Review
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3 authors.
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Abstract
backgroundG protein-coupled receptors (GPCRs) are one of the largest families of genes in mammals. Branchiostoma floridae (amphioxus) is one of the species most closely related species to vertebrates.
resultsMining and phylogenetic analysis of the amphioxus genome showed the presence of at least 664 distinct GPCRs distributed among all the main families of GPCRs; Glutamate (18), Rhodopsin (570), Adhesion (37), Frizzled (6) and Secretin (16). Surprisingly, the Adhesion GPCR repertoire in amphioxus includes receptors with many new domains not previously observed in this family. We found many Rhodopsin GPCRs from all main groups including many amine and peptide binding receptors and several previously uncharacterized expansions were also identified. This genome has however no genes coding for bitter taste receptors (TAS2), the sweet and umami (TAS1), pheromone (VR1 or VR2) or mammalian olfactory receptors.
conclusionThe amphioxus genome is remarkably rich in various GPCR subtypes while the main GPCR groups known to sense exogenous substances (such as Taste 2, mammalian olfactory, nematode chemosensory, gustatory, vomeronasal and odorant receptors) in other bilateral species are absent.
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