ReviewAmerican journal of Alzheimer's disease and other dementias
Role of insulin metabolism disturbances in the development of Alzheimer disease: mini review.
Review in American journal of Alzheimer's disease and other dementias. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Bridging pathologies: Mechanistic insights into the diabetes-Alzheimer's nexus.EXCLI journal · 2026Review
- Role of insulin resistance in Alzheimer's disease.Metabolic brain disease · 2015Review
- Experimental induction of type 2 diabetes in aging-accelerated mice triggered Alzheimer-like pathology and memory deficits.Journal of Alzheimer's disease : JAD · 2014Article
- Progress in the development of new drugs in Alzheimer's disease.The journal of nutrition, health & aging · 2011Article
- Article
- Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress.Molecular psychiatry · 2010Review
- Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease.Molecular neurodegeneration · 2010Article
- GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2010Article
- Predictors of progression of cognitive decline in Alzheimer's disease: the role of vascular and sociodemographic factors.Journal of neurology · 2009Article
- A look inside the diabetic brain: Contributors to diabetes-induced brain aging.Biochimica et biophysica acta · 2009Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer disease (AD) is the most common form of dementia. Different pathogenic processes have been studied that underlie characteristic changes of AD, including A beta protein aggregation, tau phosphorylation, neurovascular dysfunction, and inflammatory processes. Insulin exerts pleiotropic effects in neurons, such as the regulation of neural proliferation, apoptosis, and synaptic transmission. In this setting, any disturbance in the metabolism of insulin in the central nervous system (CNS) may put unfavorable effects on CNS function. It seems that disturbances in insulin metabolism, especially insulin resistance, play a role in most pathogenic processes that promote the development of AD. In this article, the relationships of disturbances in the metabolism of insulin in CNS with A beta peptides aggregation, tau protein phosphorylation, inflammatory markers, neuron apoptosis, neurovascular dysfunction, and neurotransmitter modulation are discussed, and future research directions are provided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.