ArticleBMC infectious diseases2008
Increased fluoroquinolone resistance with time in Escherichia coli from >17,000 patients at a large county hospital as a function of culture site, age, sex, and location.
Article in BMC infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Pooled it
- Spatial pattern and risk factors of resistance to important antibiotics amongAntimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Antimicrobial resistance prevalence in bloodstream infection in 29 European countries by age and sex: An observational study.PLoS medicine · 2024Observational
- A Pattern of Antibiotic Resistance in Gram-Negative Rods Causing Urinary Tract Infection in Adults.Cureus · 2021Article
- Prospective Monitoring and Adapting Strategies for Prevention of Infection Following Transrectal Prostate Procedures.Urology practice · 2018Article
- New and developing diagnostic technologies for urinary tract infections.Nature reviews. Urology · 2017Review
- Contribution of target alteration, protection and efflux pump in achieving high ciprofloxacin resistance in Enterobacteriaceae.AMB Express · 2016Article
- Susceptibility of Austrian Clinical Klebsiella and Enterobacter Isolates Linked to Patient-Related Data.Frontiers in microbiology · 2016Article
- Community acquired multi-drug resistant clinical isolates of Escherichia coli in a tertiary care center of Nepal.Antimicrobial resistance and infection control · 2015Article
- Comparison of phenotypic characteristics and antimicrobial resistance patterns of clinical Escherichia coli collected from two unrelated geographical areas.Global journal of health science · 2014Article
- Real-time detection of DNA topological changes with a fluorescently labeled cruciform.Nucleic acids research · 2013Article
- Molecular characterization of extraintestinal Escherichia coli isolates in Japan: relationship between sequence types and mutation patterns of quinolone resistance-determining regions analyzed by pyrosequencing.Journal of clinical microbiology · 2013Article
- Novel Conserved Genotypes Correspond to Antibiotic Resistance Phenotypes of E. coli Clinical Isolates.PloS one · 2013Article
- Do we really know the prevalence of multi-drug resistant Escherichia coli in the territorial and nosocomial population?Urology annals · 2013Article
- Antibiotic resistance pattern among common bacterial uropathogens with a special reference to ciprofloxacin resistant Escherichia coli.The Indian journal of medical research · 2012Article
- Control of fluoroquinolone resistance through successful regulation, Australia.Emerging infectious diseases · 2012Article
- Increased multi-drug resistant Escherichia coli from hospitals in Khartoum state, Sudan.African health sciences · 2012Article
- Bullied no more: when and how DNA shoves proteins around.Quarterly reviews of biophysics · 2012Review
- Article
- Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli.Antimicrobial agents and chemotherapy · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEscherichia coli infections are common and often treated with fluoroquinolones. Fluoroquinolone resistance is of worldwide importance and is monitored by national and international surveillance networks. In this study, we analyzed the effects of time, culture site, and patient age, sex, and location on fluoroquinolone resistance in E. coli clinical isolates.
methodsTo understand how patient factors and time influenced fluoroquinolone resistance and to determine how well data from surveillance networks predict trends at Ben Taub General Hospital in Houston, TX, we used Perl to parse and MySQL to house data from antibiograms (n congruent with 21,000) for E. coli isolated between 1999 to 2004 using Chi Square, Bonferroni, and Multiple Linear Regression methods.
resultsFluoroquinolone resistance (i) increased with time; (ii) exceeded national averages by 2- to 4-fold; (iii) was higher in males than females, largely because of urinary isolates from male outpatients; (iv) increased with patient age; (v) was 3% in pediatric patients; (vi) was higher in hospitalized patients than outpatients; (vii) was higher in sputum samples, particularly from inpatients, than all other culture sites, including blood and urine, regardless of patient location; and (viii) was lowest in genital isolates than all other culture sites. Additionally, the data suggest that, with regard to susceptibility or resistance by the Dade Behring MicroScan system, a single fluoroquinolone suffices as a "surrogate marker" for all of the fluoroquinolone tested.
conclusionLarge surveillance programs often did not predict E. coli fluoroquinolone resistance trends at a large, urban hospital with a largely indigent, ethnically diverse patient population or its affiliated community clinics.
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