ArticleAnalytical chemistry2008
Label-free plasmonic detection of biomolecular binding by a single gold nanorod.
Article in Analytical chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed.
- Phytochemical Nanoparticles for the Treatment of Neurological Disorders.Phytochemical analysis : PCA · 2025Review
- Individual ZnO-Ag Hybrid Nanorods for Synergistic Fluorescence Enhancement Towards Highly Sensitive and Miniaturized Biodetection.Nanomaterials (Basel, Switzerland) · 2025Article
- Detection of estradiol with a digital immunoassay using an anti-immunocomplex antibody and single-molecule observation of gold nanoparticles.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- Article
- Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point-of-Care: A Review of Recent Technologies.Advanced materials (Deerfield Beach, Fla.) · 2023Review
- Article
- Article
- Plasmonic phenomena in molecular junctions: principles and applications.Nature reviews. Chemistry · 2022Review
- Gold nanomaterials for optical biosensing and bioimaging.Nanoscale advances · 2021Review
- Gold Nanorods for LSPR Biosensing: Synthesis, Coating by Silica, and Bioanalytical Applications.Biosensors · 2020Review
- Critical Review: digital resolution biomolecular sensing for diagnostics and life science research.Lab on a chip · 2020Review
- Optical Interrogation Techniques for Nanophotonic Biochemical Sensors.Sensors (Basel, Switzerland) · 2019Review
- Analyzing Secondary Structure Patterns in DNA Aptamers Identified via CompELS.Molecules (Basel, Switzerland) · 2019Article
- Revealing transient events of molecular recognition via super-localization imaging of single-particle motion.Scientific reports · 2019Article
- Review
- Microfluidic Analyte Transport to Nanorods for Photonic and Electrochemical Sensing Applications.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Spatially Resolved Sensitivity of Single-Particle Plasmon Sensors.The journal of physical chemistry. C, Nanomaterials and interfaces · 2018Article
- Surface Plasmon Resonance Sensors on Raman and Fluorescence Spectroscopy.Sensors (Basel, Switzerland) · 2017Review
- Microscopic Differentiation of Plasmonic Nanoparticles for the Ratiometric Read-out of Target DNA.Scientific reports · 2017Article
- Single-Molecule Plasmon Sensing: Current Status and Future Prospects.ACS sensors · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We report the use of individual gold nanorods as plasmonic transducers to detect the binding of streptavidin to individual biotin-conjugated nanorods in real time on a surface. Label-free detection at the single-nanorod level was performed by tracking the wavelength shift of the nanorod-localized surface plasmon resonant scattering spectrum using a dark-field microspectroscopy system. The lowest streptavidin concentration that was experimentally measured was 1 nM, which is a factor of 1000-fold lower than the previously reported detection limit for streptavidin binding by biotinylated single plasmonic nanostructures. We believe that the current optical setup is able to reliably measure wavelength shifts as small as 0.3 nm. Binding of streptavidin at 1 nM concentration induces a mean resonant wavelength shift of 0.59 nm suggesting that we are currently operating at close to the limit of detection of the system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.