ArticleMolecular pharmaceutics
New ways of imaging uptake and intracellular fate of liposomal drug carrier systems inside individual cells, based on Raman microscopy.
Article in Molecular pharmaceutics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 111 citations in OpenAlex.
- The Next Frontier in Vibrational Imaging: Chemically Designed Raman Probes Pass the Spectral Barrier.JACS Au · 2026Review
- Recent advances in Raman probes for multiplexed bioimaging.Inflammation and regeneration · 2025Review
- Illuminating life processes by vibrational probes.Nature methods · 2025Review
- Biomedical applications, perspectives and tag design concepts in the cell - silent Raman window.RSC chemical biology · 2024Review
- Recent Advances in Enhancement of Raman Scattering Intensity for Biological Applications.Chemical & biomedical imaging · 2023Review
- Strategies and Progress of Raman Technologies for Cellular Uptake Analysis of the Drug Delivery Systems.International journal of nanomedicine · 2023Review
- Raman Spectroscopy for Chemical Biology Research.Journal of the American Chemical Society · 2022Review
- Raman and fluorescence micro-spectroscopy applied for the monitoring of sunitinib-loaded porous silicon nanocontainers in cardiac cells.Frontiers in pharmacology · 2022Article
- Unveiling Cancer Metabolism through Spontaneous and Coherent Raman Spectroscopy and Stable Isotope Probing.Cancers · 2021Review
- A Palette of Minimally Tagged Sucrose Analogues for Real-Time Raman Imaging of Intracellular Plant Metabolism.Angewandte Chemie (International ed. in English) · 2021Article
- A Palette of Minimally Tagged Sucrose Analogues for Real-Time Raman Imaging of Intracellular Plant Metabolism.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2021Article
- Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling.Journal of materials chemistry. B · 2020Article
- The structural fate of lipid nanoparticles in the extracellular matrix.Materials horizons · 2020Article
- Raman Imaging of Nanocarriers for Drug Delivery.Nanomaterials (Basel, Switzerland) · 2019Review
- Circulating Lipoproteins: A Trojan Horse Guiding Squalenoylated Drugs to LDL-Accumulating Cancer Cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Article
- Biokinetics of Nanomaterials: the Role of Biopersistence.NanoImpact · 2017Article
- High throughput toxicity screening and intracellular detection of nanomaterials.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2017Review
- Molecular imaging of brain localization of liposomes in mice using MALDI mass spectrometry.Scientific reports · 2016Article
- Stimulated Raman scattering microscopy: an emerging tool for drug discovery.Chemical Society reviews · 2016Review
- High resolution Raman spectroscopy mapping of stem cell micropatterns.The Analyst · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Recent developments, combining Raman spectroscopy with optical microscopy, provide a new noninvasive technique to assess and image cellular processes. Of particular interest are the uptake mechanisms of various cytologically active compounds. In order to distinguish the species of interest from their cellular environment spectroscopically, compounds may be labeled with deuterium. Here, we apply Raman microspectroscopy to follow the uptake of liposomal drug carrier systems that have been introduced to deliver biologically active compounds to their site of action within human breast adenocarcinoma MCF-7 cells. The distribution patterns of liposomes and liposomes surface-modified with a cell-penetrating peptide (TAT-peptide, TATp) have been imaged over time. The spectroscopic information obtained provides a clear evidence for variable rates, as well as different efficiencies of liposome uptake depending on their surface properties. Depending on the experimental setup, the technique may be applied to fixed or living cell organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.