ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2008
Constipation in cancer patients on morphine.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Pooled it
- Laxatives for the management of constipation in people receiving palliative care.The Cochrane database of systematic reviews · 2015Pooled it
- Constipation in people prescribed opioids.BMJ clinical evidence · 2010Pooled it
- Efficacy and safety of controlled-release oxycodone/naloxone versus controlled-release oxycodone in Korean patients with cancer-related pain: a randomized controlled trial.Chinese journal of cancer · 2017Trial
- Direct conversion from tramadol to tapentadol prolonged release for moderate to severe, chronic malignant tumour-related pain.European journal of pain (London, England) · 2016Trial
- Heroin and its metabolites: relevance to heroin use disorder.Translational psychiatry · 2023Review
- Impact of opioid-induced constipation on healthcare resource utilization and costs for cancer pain patients receiving continuous opioid therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- The Efficacy and Safety of Transcutaneous Acupoint Interferential Current Stimulation for Cancer Pain Patients With Opioid-Induced Constipation: A Prospective Randomized Controlled Study.Integrative cancer therapies · 2018Article
- Enteric Nervous System: Neuropathic Gastrointestinal Motility.Digestive diseases and sciences · 2016Article
- Constipation: opioid antagonists in people prescribed opioids.BMJ clinical evidence · 2015Review
- Genetic and Non-genetic Factors Associated With Constipation in Cancer Patients Receiving Opioids.Clinical and translational gastroenterology · 2015Article
- Predictive factors for overall quality of life in patients with advanced cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Article
- Self-reported constipation in patients with advanced cancer: a preliminary report.Journal of pain and symptom management · 2013Article
- Laxative prescriptions to cancer outpatients receiving opioids: a study from the Norwegian prescription database.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Article
- A cross-sectional study of constipation and laxative use in advanced cancer patients: insights for revision of current practice.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Article
- The role of β-arrestin2 in the mechanism of morphine tolerance in the mouse and guinea pig gastrointestinal tract.The Journal of pharmacology and experimental therapeutics · 2012Article
- Inadequate symptom control in advanced cancer patients across Europe.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2011Article
- Lubiprostone reverses the inhibitory action of morphine on mucosal secretion in human small intestine.Digestive diseases and sciences · 2011Article
- Acute abdomen in a patient with cancer pain on oxycodone.Case reports in medicine · 2011Article
- Opioid-induced constipation in advanced illness: safety and efficacy of methylnaltrexone bromide.Clinical Medicine Insights. Oncology · 2011Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
goals of workConstipation is a significant problem in patients taking morphine for cancer pain. The aims of this study were (1) to assess the magnitude of constipation in this study cohort, (2) to analyse the constipation treatment strategies and (3) to look for evidence of inter-individual variation in both susceptibility to constipation and response to treatment with laxatives in this patient group. MATERIALS AND
methodsThis was an observational study carried out in a tertiary referral cancer hospital. Two hundred seventy four patients were recruited to the study. All had a diagnosis of cancer and were on oral morphine for cancer pain. The main outcomes measured were subjective patient assessment of constipation severity in the preceding week and laxative use. Patients were asked to grade constipation in the preceding week on a four-point categorical scale: "not at all" (grade 0), "a little" (grade 1), "quite a bit" (grade 2) and "very much" (grade 3). Laxative dose groups (LDGs) were developed to assess laxative dosing.
resultsConstipation affects 72% of this cohort of patients. Constipation in this population is poorly managed. Eighty nine percent of constipated patients were on inadequate laxative therapy. Inter-individual variation in constipation on morphine exists: some patients do not experience constipation and do not need to take any laxatives, some patients do not experience constipation because they are taking laxatives and some patients experience constipation despite being on high dose laxatives. These three groups were compared in terms of cancer diagnosis, time on morphine, dose of morphine and other concomitant factors. No factor was identified to account for this inter-individual variation. Improvement in the clinical management of constipation is needed, with titration of laxatives according to individual patient need.
conclusionConstipation affects a large proportion of cancer patients taking oral morphine. Constipation in these patients is generally inadequately treated.
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