ArticleNeuroscience and behavioral physiology2008
The role of L-type calcium channels in the accumulation of Ca2+ in soleus muscle fibers in the rat and changes in the ratio of myosin and serca isoforms in conditions of gravitational unloading.
Article in Neuroscience and behavioral physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Spaceflight increases sarcoplasmic reticulum CaNPJ microgravity · 2024Article
- Calpain-dependent degradation of cytoskeletal proteins as a key mechanism for a reduction in intrinsic passive stiffness of unloaded rat postural muscle.Pflugers Archiv : European journal of physiology · 2022Article
- Review
- Calcium homeostasis during hibernation and in mechanical environments disrupting calcium homeostasis.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Review
- Remarkable preservation of Ca(2+) homeostasis and inhibition of apoptosis contribute to anti-muscle atrophy effect in hibernating Daurian ground squirrels.Scientific reports · 2016Article
- The blockade of dihydropyridine channels prevents an increase in μ-calpain level under m. soleus unloading.Doklady. Biochemistry and biophysics · 2015Article
- Tetanic contractions impair sarcomeric Z-disk of atrophic soleus muscle via calpain pathway.Molecular and cellular biochemistry · 2011Article
- Calcium-dependent signaling mechanisms and soleus fiber remodeling under gravitational unloading.Journal of muscle research and cell motility · 2008Review
- The basal calcium level in fibers of the rat soleus muscle under gravitational unloading: the mechanisms of its increase and the role in calpain activation.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sectionsArticle
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Authors and funding
4 authors.
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Abstract
Gravitational unloading is known to produce changes in the expression of a number of contractile and regulatory proteins in the soleus muscle. This applies particularly to isoforms of myosin heavy chains (MHC) and SERCA sarcoplasmic reticulum calcium pumps. Unloading increases the resting levels of extracellular calcium in soleus muscle fibers. The present study addresses verification of the hypothesis that changes in the expression of MHC and SERCA isoforms in gravitational unloading are linked with the accumulation of calcium ions in the myoplasm of muscle fibers. It is suggested that specific blockade of L-type calcium channels using nifedipine decreases the myoplasmic calcium ion concentration, thus preventing the development of changes in the expression of MHC and SERCA isoforms. A total of 36 male Wistar rats were divided into three groups: a control group, an unloading group using the Morley-Holton soleus muscle functional unloading model, and an unloading + nifedipine group, where animals received daily nifedipine (7 mg/kg/day) with their drinking water on the background of suspension. The results showed that blockade of L-type calcium channels on the background of gravitational unloading significantly decreased the extent of calcium ion accumulation in the myoplasm of soleus muscle fibers, which partly prevented the transformation of muscle fibers (in relation to the fast and slow isoforms of MHC and SERCA) to the rapid type. There was no nuclear translocation of the greater part of transcription factor NFATc1, as seen on unloading.
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