Evidence map›Paper›PMID 18197168›Full record

ReviewNature reviews. Microbiology2008

Inter-kingdom signalling: communication between bacteria and their hosts.

David T Hughes, Vanessa Sperandio

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 316 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
316citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

316 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Testosterone Modulates Virulence-Associated Phenotypes ofPathogens (Basel, Switzerland) · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Plant-Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two-Component System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. mBio · 2026
    Article
  10. Efficacy of Cannabidiol in Reducing Virulence ofInternational journal of molecular sciences · 2026
    Article
  11. Review
  12. Article
  13. Review
  14. Exploring Nonantibiotic Adjuncts: Synergistic Effects of Esmolol and Carvedilol With Tigecycline.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Article
  15. Diversity and evolution of quorum-sensing systems inFrontiers in bioinformatics · 2026
    Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Metabolic cross-talk promotes persistence ofbioRxiv : the preprint server for biology · 2025
    Article

256 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

David T HughesDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA.
Vanessa Sperandio

Funding

Molecular Biology of Francisella tularensis VirulenceP01AI055637 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI NORGARD, MICHAEL V · 2003 to 2007
$8.5M
AI-3 Inhibitors as treatment for bacterial infectionsU01AI077853 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2008 to 2012
$6.5M
Quorum sensing regulation of EHEC virulence genesR01AI053067 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2003 to 2017
$6.3M
EHEC interactions with the normal intestinal floraR21AI054468 · NIAID · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI SPERANDIO, VANESSA · 2003 to 2004
$468k
NIAID NIH HHS P01 AI055637NIAID NIH HHS R01 AI053067NIAID NIH HHS R21 AI054468NIAID NIH HHS U01 AI077853
6 · The paper itself

Abstract

Microorganisms and their hosts communicate with each other through an array of hormonal signals. This cross-kingdom cell-to-cell signalling involves small molecules, such as hormones that are produced by eukaryotes and hormone-like chemicals that are produced by bacteria. Cell-to-cell signalling between bacteria, usually referred to as quorum sensing, was initially described as a means by which bacteria achieve signalling in microbial communities to coordinate gene expression within a population. Recent evidence shows, however, that quorum-sensing signalling is not restricted to bacterial cell-to-cell communication, but also allows communication between microorganisms and their hosts.

Indexed as

Host-Pathogen InteractionsSignal Transduction4-ButyrolactoneAcyl-ButyrolactonesBacteriaEukaryotic CellsGene Expression Regulation, BacterialHormonesPlants4-ButyrolactoneAcyl-ButyrolactonesHormonesN-(3-oxohexanoyl)-3-aminodihydro-2(3H)-furanone

Identifiers

PMID18197168
PMCPMC2667375

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.