GuidelineGenetics in medicine : official journal of the American College of Medical Genetics2008
First trimester diagnosis and screening for fetal aneuploidy.
Guideline in Genetics in medicine : official journal of the American College of Medical Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- NSGC practice guideline: prenatal screening and diagnostic testing options for chromosome aneuploidy.Journal of genetic counseling · 2013Guideline
- Review
- Micrognathia as a Diagnosis Marker for the Prenatal Identification of Edwards Syndrome.Biomedicines · 2025Article
- Trends in prenatal diagnosis of congenital anomalies in Western Australia between 1980 and 2020: A population-based study.Paediatric and perinatal epidemiology · 2023Article
- Evaluation of the results of patients who applied to the Çukurova University, Medical Genetics Department for prenatal diagnosis and determination of genetic counseling principlesTurkish journal of medical sciences · 2021Article
- Effect of Shared Decision-making on Anxiety of Women Recommended for Prenatal Screening Tests in Southeast of Iran.Journal of family & reproductive health · 2020Article
- Performance and Predictive Value of First Trimester Screening Markers for Down Syndrome in Iranian Pregnancies.Journal of family & reproductive health · 2018Article
- Benefits and limitations of prenatal screening for Prader-Willi syndrome.Prenatal diagnosis · 2017Review
- Noninvasive prenatal screening for fetal aneuploidy, 2016 update: a position statement of the American College of Medical Genetics and Genomics.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Article
- Antenatal care for healthy pregnant women: a mapping of interventions from existing guidelines to inform the development of new WHO guidance on antenatal care.BJOG : an international journal of obstetrics and gynaecology · 2016Review
- Prenatal screening methods for aneuploidies.North American journal of medical sciences · 2013Article
- Prenatal testing for Down syndrome: comparison of screening practices in the UK and USA.Journal of genetic counseling · 2010Article
- The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Initiative: methods of the EGAPP Working Group.Genetics in medicine : official journal of the American College of Medical Genetics · 2009Article
- MALDI-TOF MS in Prenatal Genomics.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2009Article
- Ethical, legal, and social issues in health technology assessment for prenatal/preconceptional and newborn screening: a workshop report.Public health genomics · 2009Article
- Statement on guidance for genetic counseling in advanced paternal age.Genetics in medicine : official journal of the American College of Medical Genetics · 2008Article
- An Older Woman in Early Pregnancy: What Antenatal Screening is Appropriate?Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal serum screening for neural tube defects and fetal aneuploidy in the second trimester has been incorporated into obstetrical practice over the past two decades. Now, as a result of several multicenter trials, first trimester screening between 11 and 14 weeks has been shown to be an effective and reliable screening test for Down syndrome and trisomy 18. Benefits of first trimester screening include earlier identification of the pregnancy at risk for fetal aneuploidy and anatomic defects, in particular, cardiac anomalies, and the option of earlier diagnosis by chorionic villus sampling, if available. This policy updates the American College of Medical Genetics policy statement entitled Second Trimester Maternal Serum Screening for Fetal Open Neural Tube Defects and Aneuploidy (2004) and complements the sections of American College of Medical Genetic's Standards and Guidelines for Clinical Genetics Laboratories entitled "Prenatal screening for Down syndrome that includes first trimester biochemistry and/or ultrasound measurements."
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.