ArticleCancer biology & therapy2008
A direct protein-protein interaction is involved in the suppression of beta-catenin transcription by retinoid X receptor alpha in colorectal cancer cells.
Article in Cancer biology & therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- The phosphorylated retinoid X receptor-α promotes diethylnitrosamine-induced hepatocarcinogenesis in mice through the activation of β-catenin signaling pathway.Carcinogenesis · 2022Article
- Review
- Effects and mechanism of the bile acid (farnesoid X) receptor on the Wnt/β-catenin signaling pathway in colon cancer.Oncology letters · 2020Article
- Article
- miR-27a-3p targeting RXRα promotes colorectal cancer progression by activating Wnt/β-catenin pathway.Oncotarget · 2017Article
- Pleiotropic roles of the matricellular protein Sparc in tendon maturation and ageing.Scientific reports · 2016Article
- Effect of retinoic acid and vitamin D3 on osteoblast differentiation and activity in aging.Journal of bone and mineral metabolism · 2016Article
- Role of retinoids in the prevention and treatment of colorectal cancer.World journal of gastrointestinal oncology · 2015Review
- Decreased RXRα is Associated with Increased β-Catenin/TCF4 in (56)Fe-Induced Intestinal Tumors.Frontiers in oncology · 2015Article
- Article
- c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway.Carcinogenesis · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Using both mammalian two-hybrid assay in vivo and immunoprecipitation in vitro we found that retinoid X receptor alpha (RXR alpha) directly interacted with beta-catenin and suppressed beta-catenin transcription activity and protein expression in colorectal cancer cells. But, reduction of RXR alpha by small interfering RNA upregulated beta-catenin transcriptional activity and protein expression. However, gain- or loss-expression of beta-catenin did not affect RXR alpha. Therefore, our data provided the first evidence tht RXR alpha directly interacted with beta-catenin and regulated beta-catenin transcription, which provides important information for developing novel strategies in colorectal cancer prevention by targeting RXR alpha-beta-catenin signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.