SynthesisClinical orthopaedics and related research2008
Treatment of focal articular cartilage defects in the knee: a systematic review.
Synthesis in Clinical orthopaedics and related research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 8 syntheses or guidelines pooled it, 207 citations in OpenAlex.
- Pooled it
- Changing trends in the use of cartilage restoration techniques for the patellofemoral joint: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Pooled it
- The use of mesenchymal stem cells for cartilage repair and regeneration: a systematic review.Journal of orthopaedic surgery and research · 2017Pooled it
- The comparison between the different generations of autologous chondrocyte implantation with other treatment modalities: a systematic review of clinical trials.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Pooled it
- Clinical outcome after microfracture of the knee: a meta-analysis of before/after-data of controlled studies.International orthopaedics · 2012Pooled it
- Autologous chondrocyte implantation: a systematic review.The Journal of bone and joint surgery. American volume · 2010Pooled it
- Knee pain and mobility impairments: meniscal and articular cartilage lesions.The Journal of orthopaedic and sports physical therapy · 2010Guideline
- Pooled it
- Two-Year Follow-Up and Remodeling Kinetics of ChonDux Hydrogel for Full-Thickness Cartilage Defect Repair in the Knee.Cartilage · 2020Trial
- Trial
- Microfracture technique versus osteochondral autologous transplantation mosaicplasty in patients with articular chondral lesions of the knee: a prospective randomized trial with long-term follow-up.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014Trial
- Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results.Arthritis research & therapy · 2009Trial
- Patient and Chondral Defect-Specific Characteristics an Associated Matrix-Induced Autologous Chondrocyte Implantation Conversion Rates Following Biopsy.Orthopaedic journal of sports medicine · 2026Article
- A Critical Appraisal of Reporting Bias in Systematic Reviews and Meta-Analyses Addressing Knee Chondral Defects.Cartilage · 2025Article
- Review
- Knee focal cartilage defect location heat map and local surface morphology characterisation: Insights for focal knee resurfacing implant design.Journal of experimental orthopaedics · 2025Article
- Effect of N-butyl cyanoacrylate on the regeneration of joint defects in mature male rats.Veterinary research forum : an international quarterly journal · 2025Article
- Histological Evaluation of the Effects of Intra-Articular Injection of Caffeic Acid on Cartilage Repair in a Rat Knee Microfracture Model.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Microfragmented Adipose Tissue Associated With Collagen Membrane in the Treatment of Focal Knee Cartilage Defect.Arthroscopy techniques · 2024Article
- Advanced therapy with mesenchymal stromal cells for knee osteoarthritis: Systematic review and meta-analysis of randomized controlled trials.Journal of orthopaedic translation · 2024Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledWe asked whether autologous chondrocyte implantation or osteochondral autograft transfer yields better clinical outcomes compared with one another or with traditional abrasive techniques for treatment of isolated articular cartilage defects and whether lesion size influences this clinical outcome. We performed a literature search and identified five randomized, controlled trials and one prospective comparative trial evaluating these treatment techniques in 421 patients. The operative procedures included autologous chondrocyte implantation, osteochondral autograft transfer, matrix-induced autologous chondrocyte implantation, and microfracture. Minimum followup was 1 year (mean, 1.7 years; range, 1-3 years). All studies documented greater than 95% followup for clinical outcome measures. No technique consistently had superior results compared with the others. Outcomes for microfracture tended to be worse in larger lesions. All studies reported improvement in clinical outcome measures in all treatment groups when compared with preoperative assessment; however, no control (nonoperative) groups were used in any of the studies. A large prospective trial investigating these techniques with the addition of a control group would be the best way to definitively address the clinical questions. LEVEL OF EVIDENCE: Level II, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.