ArticleRheumatology international2008
Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility.
Article in Rheumatology international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 6 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Ándalus project.Rheumatology (Oxford, England) · 2022Pooled it
- Association between the COMT Val158Met polymorphism and fibromyalgia susceptibility and fibromyalgia impact questionnaire score: a meta-analysis.Rheumatology international · 2015Pooled it
- Aquatic exercise training for fibromyalgia.The Cochrane database of systematic reviews · 2014Pooled it
- Meta-analysis reveals a lack of association between a common catechol-O-methyltransferase (COMT) polymorphism val¹⁵⁸met and fibromyalgia.International journal of clinical and experimental pathology · 2014Pooled it
- Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region.Annals of the rheumatic diseases · 2013Pooled it
- Candidate gene studies of fibromyalgia: a systematic review and meta-analysis.Rheumatology international · 2012Pooled it
- Relationship Between Central Sensitization and Genetic Polymorphisms-A Case-Control Study in Fibromyalgia.European journal of pain (London, England) · 2026Trial
- Trial
- A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia.Biomedicines · 2023Review
- Genetic Variations and Health-Related Quality of Life (HRQOL): A Genome-Wide Study Approach.Cancers · 2021Article
- Impact of water therapy on pain management in patients with fibromyalgia: current perspectives.Journal of pain research · 2019Article
- New insights into the genetics of fibromyalgia.The Korean journal of internal medicine · 2017Review
- Assessment of Pain Sensitivity in Patients With Chronic Low Back Pain and Association With HTR2A Gene Polymorphism.Archives of rheumatology · 2017Article
- Fibromyalgia: A Critical and Comprehensive Review.Clinical reviews in allergy & immunology · 2015Review
- Exploring Genetic Susceptibility to Fibromyalgia.Chonnam medical journal · 2015Review
- Assessment of opioid receptor μ1 gene A118G polymorphism and its association with pain intensity in patients with fibromyalgia.Rheumatology international · 2014Article
- Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision.Neuromolecular medicine · 2014Observational
- Epigenetic alterations and an increased frequency of micronuclei in women with fibromyalgia.Nursing research and practice · 2013Article
- Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgia.Arthritis and rheumatism · 2012Article
- Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome.Pain research and treatment · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic and environmental factors are thought to play roles in the etiopathology of fibromyalgia syndrome (FMS). The objective of this study was to determine the potential effects of single nucleotide polymorphisms (SNPs) in catechol-O-methyltransferase (COMT) (rs4680) and 5-hydroxytryptamine (serotonin) 2A (5-HT2A) receptor (rs6313 and rs6311) genes on susceptibility to FMS. One hundred seventy-one women (80 FMS, 91 control) were enrolled in the study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for the genotyping analyses. Genotype and allele frequencies were calculated by the chi-square test. Beck depression inventory, state and trait anxiety inventory and symptom checklist-90 revised (SCL-90-R) tests were applied to both patients and controls. There were no observed differences in the frequencies of alleles and genotypes between patients and controls for the COMT, and the two 5-HT2A receptor gene polymorphisms (P>0.05). Our results suggest that the investigated polymorphisms seem not to be the susceptibility factors in etiology of FMS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.