ArticleRheumatology international2008
Serum leptin in systemic lupus erythematosus.
Article in Rheumatology international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Emerging role of leptin in rheumatoid arthritis.Clinical and experimental immunology · 2014Pooled it
- Body Weight-Related Differences in Adipokines and Inflammatory Markers Among Women with Systemic Lupus Erythematosus.Journal of inflammation research · 2026Article
- Non-Traditional Pro-Inflammatory and Pro-Atherosclerotic Risk Factors Related to Systemic Lupus Erythematosus.International journal of molecular sciences · 2022Review
- Cardiovascular disease in systemic lupus erythematosus.Rheumatology and immunology research · 2021Review
- Role of serum leptin levels and leptin receptor gene polymorphisms in systemic lupus erythematosus.Clinical rheumatology · 2020Article
- The role of leptin in selected skin diseases.Lipids in health and disease · 2020Review
- Serum adipokine levels in patients with sarcoidosis.Clinical rheumatology · 2020Article
- Clinical associations of serum leptin and leptin/adiponectin ratio in systemic sclerosis.Postepy dermatologii i alergologii · 2019Article
- What is the role of adipokines in myasthenia gravis?Therapeutics and clinical risk management · 2018Article
- The relationship between serum leptin level and disease activity and inflammatory markers in fibromyalgia patients.Northern clinics of Istanbul · 2018Article
- Association of leptin and leptin receptor gene polymorphisms with systemic lupus erythematosus in a Chinese population.Journal of cellular and molecular medicine · 2017Article
- Emerging role of adipokines in systemic lupus erythematosus.Immunologic research · 2016Review
- Resistin as a potential marker of renal disease in lupus nephritis.Clinical and experimental immunology · 2015Article
- Fish oil N-3 fatty acids increase adiponectin and decrease leptin levels in patients with systemic lupus erythematosus.Marine drugs · 2015Article
- Pathogenesis and treatment of atherosclerosis in lupus.Rheumatic diseases clinics of North America · 2014Review
- Relationship between serum leptin level and disease activity in patients with systemic sclerosis.Clinical rheumatology · 2014Article
- Adipokines, metabolic syndrome and rheumatic diseases.Journal of immunology research · 2014Review
- Role of leptin in autoimmune diseases.Maedica · 2013Article
- Decreased serum level of soluble-leptin-receptor in patients with systemic lupus erythematosus.Iranian Red Crescent medical journal · 2012Article
- The role of adipokines in connective tissue diseases.European journal of nutrition · 2012Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptin, a peptide hormone, plays an essential role in the regulation of body weight, the endocrine function, reproduction, the immune response and inflammation. The immune system, in turn, modifies leptin's production. Systemic lupus erythematosus (SLE) is an autoimmunological disease characterized by widespread inflammation with possible involvement of each body organ and system. In this study, we assessed serum leptin levels in SLE patients and the control group in search for correlations between leptin concentrations and other markers' level, the activity of the disease, its duration, the age of the patients and their bone mineral density. Blood samples were collected from 30 SLE and 30 control group women. Each SLE patient was matched with one from the control for age (+/-1 year) and the body mass index (BMI; +/-1). Serum leptin levels were determined using the DRG Leptin ELISA Kit. Serum leptin levels in SLE patients ranged from 1.8 to 66.3 ng/ml (median value 7.5), and in control group it was 8.8 ng/ml (0.7-39.2) (NS). In SLE, serum leptin levels (after the logarithmic transformation) correlated with BMI (r = 0.89, P < 0.0001), the age (r = 0.34, P < 0.01) and the patients' disease duration (r = 0.59, P < 0.0005). Serum leptin levels in SLE patients with arthritis (P < 0.05) and central nervous system (CNS) involvement (P = 0.05) were significantly lower in comparison with serum leptin levels in SLE patients without arthritis and CNS involvement. No correlation was found between serum leptin levels and the T-score. In the control group, the logarithmic transformation of serum leptin levels positively correlated with BMI (r = 0.52, P < 0.05). No differences in serum leptin levels were shown between SLE patients and the control group. However, we found correlation between BMI and serum leptin levels in both groups. Furthermore, serum leptin levels in SLE patients with arthritis and CNS involvement were significantly lower in comparison with SLE patients without arthritis and CNS involvement, which suggests that active chronic inflammation may lower plasma leptin concentrations.
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