ArticleEuropean journal of clinical pharmacology2008
The association between antidepressant use and disturbances in glucose homeostasis: evidence from spontaneous reports.
Article in European journal of clinical pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Incident diabetes in adolescents using antidepressant: a systematic review and meta-analysis.European child & adolescent psychiatry · 2025Pooled it
- The risk of new-onset diabetes in antidepressant users - A systematic review and meta-analysis.PloS one · 2017Pooled it
- Use of antidepressant medication and risk of type 2 diabetes: results from three cohorts of US adults.Diabetologia · 2012Pooled it
- A psychoeducational intervention (SWEEP) for depressed women with diabetes.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2012Trial
- Effect of a Combined Antidepressant Drug Flupentixol-Melitracen on Glucose Level and Expression of Insulin-Like Peptide Genes DILP5 and DILP6 in Drosophila melanogaster.BioMed research international · 2026Article
- Alcohol Consumption Is a Coping Mechanism for Male Patients with Severe Anxiety Disorders Treated with Antidepressants Monotherapy.Journal of clinical medicine · 2024Article
- Article
- Venlafaxine-induced serotonin syndrome causing bilateral cerebral strokes: a case report.Frontiers in stroke · 2024Article
- A Case Report of Rare Adverse Events Associated with Venlafaxine Administration: Hypoglycemia and Lactic Acidosis.Korean journal of family medicine · 2022Article
- Identifying patients at increased risk of hypoglycaemia in primary care: Development of a machine learning-based screening tool.Diabetes/metabolism research and reviews · 2021Article
- Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia.Journal of medicinal chemistry · 2021Article
- Association between Depression, Antidepression Medications, and the Risk of Developing Type 2 Diabetes Mellitus: A Nationwide Population-Based Retrospective Cohort Study in Taiwan.BioMed research international · 2021Article
- Antidepressant use during pregnancy and the risk of gestational diabetes mellitus: a nested case-control study.BMJ open · 2019Article
- Effect of Pregnancy on Paroxetine-Induced Adiposity and Glucose Intolerance in Mice.The Journal of pharmacology and experimental therapeutics · 2019Article
- Role of Serotonin Transporter in Antidepressant-Induced Diabetes Mellitus: A Pharmacoepidemiological-Pharmacodynamic Study in VigiBaseDrug safety · 2018Article
- Detecting a potential safety signal of antidepressants and type 2 diabetes: a pharmacovigilance-pharmacodynamic study.British journal of clinical pharmacology · 2018Article
- The Bidirectional Association Between Depression and Severe Hypoglycemic and Hyperglycemic Events in Type 1 Diabetes.Diabetes care · 2018Article
- Monitoring of somatic parameters at outpatient departments for mood and anxiety disorders.PloS one · 2018Article
- Association of Antidepressant Medications With Incident Type 2 Diabetes Among Medicaid-Insured Youths.JAMA pediatrics · 2017Article
- Rasagiline-induced severe recurrent hypoglycemia in a young woman without diabetes: a case report.Journal of medical case reports · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDepression is common in patients with diabetes, and the use of antidepressants may impair glycaemic control. We assessed the association between antidepressant use and hyper- and hypoglycaemia.
methodsBased on spontaneous reports listed in the World Health Organization (WHO) Adverse Drug Reaction Database, a case-control study was conducted. The study base consisted of all adverse drug reactions (ADRs) ascribed to antidepressants, antipsychotics and benzodiazepines between 1969 and 2005. Cases were defined as reported ADRs classified as hyper- or hypoglycaemia and separated in different study populations. All other reports were considered as controls. Exposure to antidepressants was the primary determinant investigated. Benzodiazepines and antipsychotics were chosen as reference groups. Potential confounding factors, namely, age, gender, use of antidiabetic medication, use of hyper- or hypoglycaemia-inducing comedication and reporting year, were determined on the index date. Multivariate logistic regression was used to evaluate the strength of the association, which was expressed as reporting odds ratios (RORs) with 95% confidence intervals (95% CI).
resultsOverall, the use of antidepressants was associated with hyperglycaemia [ROR 1.52 (95% CI: 1.20-1.93)] and of hypoglycaemia [ROR 1.84 (95% CI: 1.40-2.42)]. The association with hyperglycaemia was most pronounced for antidepressants with affinity for the 5-HT(2c) receptor, histamine-(1) receptor and norepinephrinic (NE) reuptake transporter. The association with hypoglycaemia was most pronounced for antidepressants with affinity for the serotonin reuptake transporter.
conclusionThe results of this study strengthen the findings in individual case reports that the use of antidepressants is associated with disturbances in glucose homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.