ReviewJournal of molecular medicine (Berlin, Germany)2008
New developments in understanding and treating neuroinflammation.
Review in Journal of molecular medicine (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Mitoxantrone induces natural killer cell maturation in patients with secondary progressive multiple sclerosis.PloS one · 2012Trial
- Dexmedetomidine Ameliorates Postoperative Cognitive Dysfunction in Aged Mice.Neurochemical research · 2021Article
- Translation Imaging in Parkinson's Disease: Focus on Neuroinflammation.Frontiers in aging neuroscience · 2020Article
- Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.Journal of neuroinflammation · 2019Article
- Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway.Biomolecules & therapeutics · 2019Article
- Acetaminophen attenuates lipopolysaccharide-induced cognitive impairment through antioxidant activity.Journal of neuroinflammation · 2017Article
- Exposure of Adolescent Mice to Delta-9-Tetrahydrocannabinol Induces Long-Lasting Modulation of Pro- and Anti-Inflammatory Cytokines in Hypothalamus and Hippocampus Similar to that Observed for Peripheral Macrophages.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2015Article
- Article
- Vascular damage: a persisting pathology common to Alzheimer's disease and traumatic brain injury.Medical hypotheses · 2013Article
- Eradication of Helicobacter pylori Is Associated with the Progression of Dementia: A Population-Based Study.Gastroenterology research and practice · 2013Article
- A cannabigerol quinone alleviates neuroinflammation in a chronic model of multiple sclerosis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Article
- Dynamics of rabbit brain edema in focal lesion and perilesion area after traumatic brain injury: a MRI study.Journal of neurotrauma · 2012Article
- Targeting NOX enzymes in the central nervous system: therapeutic opportunities.Cellular and molecular life sciences : CMLS · 2012Review
- G protein-coupled receptors as therapeutic targets for multiple sclerosis.Cell research · 2012Review
- Analyses of phenotypic and functional characteristics of CX3CR1-expressing natural killer cells.Immunology · 2011Article
- Proteomic analysis of aqueous humor from patients with primary open angle glaucoma.Molecular vision · 2010Article
- Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury.Nature reviews. Neurology · 2010Review
- Astrocyte- and endothelial-targeted CCL2 conditional knockout mice: critical tools for studying the pathogenesis of neuroinflammation.Journal of molecular neuroscience : MN · 2009Article
- Attenuation of oxidative stress, inflammation and apoptosis by minocycline prevents retrovirus-induced neurodegeneration in mice.Brain research · 2009Article
- Acetaminophen inhibits neuronal inflammation and protects neurons from oxidative stress.Journal of neuroinflammation · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We are currently witnesses to and authors of a paradigm shift in neuropathology. While classical acute and chronic neuroinflammatory diseases such as meningitis or multiple sclerosis (MS) present aspects of neurodegeneration, the disease course of progressive degenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), or stroke-mediated neuronal deficit are demonstrably affected by inflammation. These insights have immediate consequences both for research methods and for the development of novel, more efficient therapies for these diseases. In this review, we analyze the inflammatory and degenerative pathological mechanisms in the brain with particular emphasis on the classical chronic inflammatory disease MS. We demonstrate that the latest pathological considerations not only require the application of advanced research technologies to investigate new pathomechanistic pathways, but also affect the investigation, development, and monitoring of novel potential therapeutic tools.
Indexed as
Identifiers
18196212What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.