ArticlePloS one2008
Correction of population stratification in large multi-ethnic association studies.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 6 syntheses or guidelines pooled it, 68 citations in OpenAlex.
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- The Trp719Arg polymorphism of the KIF6 gene and coronary heart disease risk: systematic review and meta-analysis.Hereditas · 2015Pooled it
- Association of VEGF genetic polymorphisms with recurrent spontaneous abortion risk: a systematic review and meta-analysis.PloS one · 2015Pooled it
- E-cadherin gene methylation in lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Seven functional polymorphisms in the CETP gene and myocardial infarction risk: a meta-analysis and meta-regression.PloS one · 2014Pooled it
- BRCA2 variants and cardiovascular disease in a multi-ethnic study.BMC medical genetics · 2012Pooled it
- Evidence for Epistatic Interaction betweenCells · 2023Article
- Genetic variation ineLife · 2022Article
- Re-situations of scientific knowledge: a case study of a skirmish over clusters vs clines in human population genomics.History and philosophy of the life sciences · 2022Article
- Robust Rare-Variant Association Tests For Quantitative Traits in General Pedigrees.Statistics in biosciences · 2018Article
- Correcting for Population Stratification Reduces False Positive and False Negative Results in Joint Analyses of Host and Pathogen Genomes.Frontiers in genetics · 2018Article
- Genetic variants specific to aging-related verbal memory: Insights from GWASs in a population-based cohort.PloS one · 2017Article
- Differential prevalence and associations of overweight and obesity by gender and population group among school learners in South Africa: a cross-sectional study.BMC obesity · 2017Article
- Complex disease and phenotype mapping in the domestic dog.Nature communications · 2016Article
- Is MTHFD1 polymorphism rs 2236225 (c.1958G>A) associated with the susceptibility of NSCL/P? A systematic review and meta-analysis.F1000Research · 2015Article
- Exploring unknowns in cardiology.Nature reviews. Cardiology · 2014Review
- MAPT as a predisposing gene for sporadic amyotrophic lateral sclerosis in the Chinese Han population.Neural regeneration research · 2013Article
- Article
- Understanding the population structure of North American patients with cystic fibrosis.Clinical genetics · 2011Article
- Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe vast majority of genetic risk factors for complex diseases have, taken individually, a small effect on the end phenotype. Population-based association studies therefore need very large sample sizes to detect significant differences between affected and non-affected individuals. Including thousands of affected individuals in a study requires recruitment in numerous centers, possibly from different geographic regions. Unfortunately such a recruitment strategy is likely to complicate the study design and to generate concerns regarding population stratification. METHODOLOGY/PRINCIPAL
findingsWe analyzed 9,751 individuals representing three main ethnic groups - Europeans, Arabs and South Asians - that had been enrolled from 154 centers involving 52 countries for a global case/control study of acute myocardial infarction. All individuals were genotyped at 103 candidate genes using 1,536 SNPs selected with a tagging strategy that captures most of the genetic diversity in different populations. We show that relying solely on self-reported ethnicity is not sufficient to exclude population stratification and we present additional methods to identify and correct for stratification. CONCLUSIONS/SIGNIFICANCE: Our results highlight the importance of carefully addressing population stratification and of carefully "cleaning" the sample prior to analyses to obtain stronger signals of association and to avoid spurious results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.