ArticleMolecular psychiatry2008
Genotype patterns that contribute to increased risk for or protection from developing heroin addiction.
Article in Molecular psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 102 citations in OpenAlex.
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- Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid-Related Loci as the Main Driver of Opioid Use Disorder.Genetic epidemiology · 2025Article
- Genetic Variants Linked to Opioid Addiction: A Genome-Wide Association Study.International journal of molecular sciences · 2024Article
- OPRM1 Gene Polymorphism in Women with Alcohol Use Disorder.International journal of molecular sciences · 2024Article
- Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.Scientific reports · 2022Article
- Risk score prediction model based on single nucleotide polymorphism for predicting malaria: a machine learning approach.BMC bioinformatics · 2022Article
- Leveraging Mann-Whitney U test on large-scale genetic variation data for analysing malaria genetic markers.Malaria journal · 2022Article
- Bidirectional influence of heroin and cocaine escalation in persons with dual opioid and cocaine dependence diagnoses.Experimental and clinical psychopharmacology · 2022Article
- Mysterious long noncoding RNAs and their relationships to human disease.Frontiers in molecular biosciences · 2022Review
- Pharmacogenetics of Addiction Therapy.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Genomic and Personalized Medicine Approaches for Substance Use Disorders (SUDs) Looking at Genome-Wide Association Studies.Biomedicines · 2021Review
- Age of onset of heaviest use of cannabis or alcohol in persons with severe opioid or cocaine use disorders.Drug and alcohol dependence · 2021Observational
- Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations.Frontiers in pharmacology · 2021Review
- The molecular neurobiology and neuropathology of opioid use disorder.Current research in neurobiology · 2021Article
- Haplotype-Based Association and In Silico Studies of OPRM1 Gene Variants with Susceptibility to Opioid Dependence Among Addicted Iranians Undergoing Methadone Treatment.Journal of molecular neuroscience : MN · 2020Article
- Pharmacogenomics of Pain Management: The Impact of Specific Biological Polymorphisms on Drugs and Metabolism.Current oncology reports · 2020Review
- Prolonged Withdrawal From Escalated Oxycodone Is Associated With Increased Expression of Glutamate Receptors in the Rat Hippocampus.Frontiers in neuroscience · 2020Article
- A review of opioid addiction genetics.Current opinion in psychology · 2019Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
A genome-wide association study was conducted using microarray technology to identify genes that may be associated with the vulnerability to develop heroin addiction, using DNA from 104 individual former severe heroin addicts (meeting Federal criteria for methadone maintenance) and 101 individual control subjects, all Caucasian. Using separate analyses for autosomal and X chromosomal variants, we found that the strongest associations of allele frequency with heroin addiction were with the autosomal variants rs965972, located in the Unigene cluster Hs.147755 (experiment-wise q=0.053), and rs1986513 (q=0.187). The three variants exhibiting the strongest association with heroin addiction by genotype frequency were rs1714984, located in an intron of the gene for the transcription factor myocardin (P=0.000022), rs965972 (P=0.000080) and rs1867898 (P=0.000284). One genotype pattern (AG-TT-GG) was found to be significantly associated with developing heroin addiction (odds ratio (OR)=6.25) and explained 27% of the population attributable risk for heroin addiction in this cohort. Another genotype pattern (GG-CT-GG) of these variants was found to be significantly associated with protection from developing heroin addiction (OR=0.13), and lacking this genotype pattern explained 83% of the population attributable risk for developing heroin addiction. Evidence was found for involvement of five genes in heroin addiction, the genes coding for the mu opioid receptor, the metabotropic receptors mGluR6 and mGluR8, nuclear receptor NR4A2 and cryptochrome 1 (photolyase-like). This approach has identified several new genes potentially associated with heroin addiction and has confirmed the role of OPRM1 in this disease.
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Registered trials
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