SynthesisCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2008
Fish-oil supplementation in patients with implantable cardioverter defibrillators: a meta-analysis.
Synthesis in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Omega-3 fatty acids in high-risk cardiovascular patients: a meta-analysis of randomized controlled trials.BMC cardiovascular disorders · 2010Pooled it
- Omega-3 dietary supplements and the risk of cardiovascular events: a systematic review.Clinical cardiology · 2009Pooled it
- Effect of fish oil on ventricular tachyarrhythmia in three studies in patients with implantable cardioverter defibrillators.European heart journal · 2009Pooled it
- Effect of fish oil on arrhythmias and mortality: systematic review.BMJ (Clinical research ed.) · 2008Pooled it
- Hepatoprotective and Anti-Obesity Properties of Sardine By-Product Oil in Rats Fed a High-Fat Diet.Preventive nutrition and food science · 2021Article
- Prevention of Cardiovascular Events with Omega-3 Polyunsaturated Fatty Acids and the Mechanism Involved.Journal of atherosclerosis and thrombosis · 2020Review
- Chemical composition and antibacterial activity of oils from Chrysicthys nigrodigitatus and Hepsetus odoe, two freshwater fishes from Yabassi, Cameroon.Lipids in health and disease · 2018Article
- N-3 fatty acids for prevention of cardiovascular disease.Current atherosclerosis reports · 2014Review
- Omega-3 fatty acids: a growing ocean of choices.Current atherosclerosis reports · 2014Review
- Dietary omega-3 fatty acids and susceptibility to ventricular fibrillation: lack of protection and a proarrhythmic effect.Circulation. Arrhythmia and electrophysiology · 2012Article
- The role of long-chained marine N-3 polyunsaturated Fatty acids in cardiovascular disease.Cardiology research and practice · 2012Article
- Concordance of randomized and nonrandomized studies was unrelated to translational patterns of two nutrient-disease associations.Journal of clinical epidemiology · 2012Article
- Why Do We Still Need Large Scale Clinical Trial: The Case of n-3 PUFA.Frontiers in physiology · 2012Article
- Omega-3 polyunsaturated fatty acids and cardiac rhythm: an introduction.Frontiers in physiology · 2012Article
- The effects of supplementation with omega-3 polyunsaturated Fatty acids on cardiac rhythm: anti-arrhythmic, pro-arrhythmic, both or neither? It depends….Frontiers in physiology · 2012Article
- Omega-3 Index and sudden cardiac death.Nutrients · 2010Review
- The response to fish oil in patients with heart disease depends on the predominant arrhythmia mechanism.Cardiovascular drugs and therapy · 2009Article
- Association between n-3 fatty acid consumption and ventricular ectopy after myocardial infarction.The American journal of clinical nutrition · 2009Article
- Are dietary recommendations for the use of fish oils sustainable?CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2009Article
- Should patients with cardiovascular disease take fish oil?CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2008Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA recent Cochrane meta-analysis did not confirm the benefits of fish and fish oil in the secondary prevention of cardiac death and myocardial infarction. We performed a meta-analysis of randomized controlled trials that examined the effect of fish-oil supplementation on ventricular fibrillation and ventricular tachycardia to determine the overall effect and to assess whether heterogeneity exists between trials.
methodsWe searched electronic databases (MEDLINE, EMBASE, The Cochrane Central Register of Controlled Trials, CINAHL) from inception to May 2007. We included randomized controlled trials of fish-oil supplementation on ventricular fibrillation or ventricular tachycardia in patients with implantable cardioverter defibrillators. The primary outcome was implantable cardioverter defibrillator discharge. We calculated relative risk [RR] for outcomes at 1-year follow-up for each study. We used the DerSimonian and Laird random-effects methods when there was significant heterogeneity between trials and the Mantel-Hanzel fixed-effects method when heterogeneity was negligible.
resultsWe identified 3 trials of 1-2 years' duration. These trials included a total of 573 patients who received fish oil and 575 patients who received a control. Meta-analysis of data collected at 1 year showed no overall effect of fish oil on the relative risk of implantable cardioverter defibrillator discharge. There was significant heterogeneity between trials. The second largest study showed a significant benefit of fish oil (relative risk [RR] 0.74, 95% confidence interval [CI] 0.56-0.98). The smallest showed an adverse tendency at 1 year (RR 1.23, 95% CI 0.92-1.65) and significantly worse outcome at 2 years among patients with ventricular tachycardia at study entry (log rank p = 0.007).
conclusionThese data indicate that there is heterogeneity in the response of patients to fish-oil supplementation. Caution should be used when prescribing fish-oil supplementation for patients with ventricular tachycardia.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.