Evidence map›Paper›PMID 18195067›Full record

ArticleAntimicrobial agents and chemotherapy2008

In vitro activities of 35 double combinations of antifungal agents against Scedosporium apiospermum and Scedosporium prolificans.

Manuel Cuenca-Estrella, Ana Alastruey-Izquierdo, Laura Alcazar-Fuoli, Leticia Bernal-Martinez, Alicia Gomez-Lopez, Maria J Buitrago, Emilia Mellado, Juan L Rodriguez-Tudela

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Dematiaceous Molds.Infectious disease clinics of North America · 2025
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  7. Pathogens (Basel, Switzerland) · 2022
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  8. Non-European respiratory review : an official journal of the European Respiratory Society · 2022
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  9. Microorganisms · 2022
    Review
  10. Article
  11. Miltefosine AgainstFrontiers in cellular and infection microbiology · 2021
    Article
  12. Eradication ofCase reports in orthopedics · 2020
    Article
  13. Therapeutic Challenges of Non-Antimicrobial agents and chemotherapy · 2019
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. SUSCEPTIBILITY TEST FOR FUNGI: CLINICAL AND LABORATORIAL CORRELATIONS IN MEDICAL MYCOLOGY.Revista do Instituto de Medicina Tropical de Sao Paulo · 2015
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Manuel Cuenca-EstrellaServicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra Majadahonda-Pozuelo Km 2, 28220 Majadahonda Madrid, Spain. mcuenca-estrella@isciii.es
Ana Alastruey-Izquierdo
Laura Alcazar-Fuoli
Leticia Bernal-Martinez
Alicia Gomez-Lopez
Maria J Buitrago
Emilia Mellado
Juan L Rodriguez-Tudela

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activities of 35 combinations of antifungal agents against Scedosporium spp. were analyzed by a checkerboard microdilution design and the summation of fractional concentration index. An average indifferent effect was detected apart from combinations of azole agents and echinocandins against Scedosporium apiospermum. Antagonism was absent for all antifungal combinations against both species.

Indexed as

Antifungal AgentsDrug InteractionsDrug SynergismDrug Therapy, CombinationHumansMicrobial Sensitivity TestsMycetomaScedosporiumAntifungal Agents

Identifiers

PMID18195067
PMCPMC2258535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.