Evidence map›Paper›PMID 18195060›Full record

ArticleAntimicrobial agents and chemotherapy2008

Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event.

Daniel R Gentry, David J Holmes

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Molecular Mechanism ofInfection and drug resistance · 2022
    Article
  3. Article
  4. Article
  5. Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  6. Article
  7. Newer antibacterial drugs for a new century.Expert opinion on investigational drugs · 2010
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Daniel R GentryDepartment of Microbiology, ID-CEDD, GlaxoSmithKline, Collegeville, Pennsylvania 19426, USA. dan.r.gentry@gsk.com
David J Holmes
GlaxoSmithKline (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While most Staphylococcus aureus telithromycin-resistant mutants isolated in this study possessed duplications within rplV (encoding ribosomal protein L22), four isolates possessed insertions within rplV that were identical to a portion of the gene rplB (encoding ribosomal protein L2). This novel type of mutation is the result of an apparent gene conversion-like event.

Indexed as

Gene ConversionMutationAmino Acid SequenceAnti-Bacterial AgentsBase SequenceDrug Resistance, BacterialKetolidesMicrobial Sensitivity TestsMolecular Sequence DataRibosomal ProteinsStaphylococcus aureusAnti-Bacterial AgentsKetolidesribosomal protein L2Ribosomal Proteinstelithromycin

Identifiers

PMID18195060
PMCPMC2258494
OpenAlexW2144443862

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.