ArticleMolecular and cellular biology2008
The Wnt pool of glycogen synthase kinase 3beta is critical for trophic-deprivation-induced neuronal death.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Lithium chloride in vitro treatment shows potential to rescue the neuronal phenotype caused by WDFY3 haploinsufficiency.Molecular psychiatry · 2026Article
- GSK3β Inhibition by Phosphorylation at SerInternational journal of molecular sciences · 2022Article
- Functional Genomic Insights into ProbioticFoods (Basel, Switzerland) · 2021Article
- Regulation of GSK3β by SerMolecular neurobiology · 2021Article
- Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources.Current neuropharmacology · 2021Article
- Article
- GSK-3β Contributes to Parkinsonian Dopaminergic Neuron Death: Evidence From Conditional Knockout Mice and Tideglusib.Frontiers in molecular neuroscience · 2020Article
- Failure to Inactivate Nuclear GSK3β by SerNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination.Frontiers in cellular neuroscience · 2014Article
- The nuclear localization of glycogen synthase kinase 3β is required its putative PY-nuclear localization sequences.Molecules and cells · 2012Article
- Calpains are downstream effectors of bax-dependent excitotoxic apoptosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib.The Journal of biological chemistry · 2012Article
- Lentivirally mediated GSK-3β silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice.The international journal of neuropsychopharmacology · 2011Article
- Role of STRAP in regulating GSK3β function and Notch3 stabilization.Cell cycle (Georgetown, Tex.) · 2011Article
- Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis.Journal of hepatology · 2011Article
- Egr-1 transactivates Bim gene expression to promote neuronal apoptosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS.Frontiers in molecular neuroscience · 2011Article
- Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival.The Journal of biological chemistry · 2010Article
- Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles.Nature neuroscience · 2010Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycogen synthase kinase 3 (GSK-3) is implicated in neuronal death through a causal role, and precise mechanisms have not been unambiguously defined. We show that short hairpin RNA (shRNA) knockdown of GSK-3beta, but not GSK-3alpha, protects cerebellar granule neurons from trophic-deprivation-induced death. Using compartment-targeted inhibitors of the Wnt-regulated GSK-3 pool, NLS-FRAT1, NES-FRAT1, and axin-GSK-3-interacting domain (axin-GID), we locate proapoptotic GSK-3 action to the cytosol and regulation of Bim protein turnover despite constitutive cycling of GSK-3 between the cytosol and nucleus, revealed by leptomycin B. We examine the importance of Ser21/9 (GSK-3alpha/beta) phosphorylation on proapoptotic GSK-3 function. Neurons isolated from GSK-3alpha/beta(S21A/S9A) knock-in mice survive normally and are fully sensitive to trophic-deprivation-induced death. Nonetheless, inhibition of GSK-3 catalytic activity with lithium or SB216763 protects GSK-3alpha/beta(S21A/S9A) neurons from death. This indicates that dephosphorylation of GSK-3beta/Ser9 and GSK-3alpha/Ser21 is insufficient for GSK-3 proapoptotic function and that another level of regulation is required. Gel filtration reveals a stress-induced loss of neuronal GSK-3beta from a high-molecular-mass complex with a concomitant decrease in axin-bound GSK-3beta. These data imply that Wnt-regulated GSK-3beta plays a nonredundant role in trophic-deprivation-induced death of neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.