ArticleMolecular and cellular biology2008
Regulation of lymphocyte development by cell-type-specific interpretation of Notch signals.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Protein ubiquitination in T cell development.Frontiers in immunology · 2022Review
- The divergence between T cell and innate lymphoid cell fates controlled by E and Id proteins.Frontiers in immunology · 2022Review
- E Protein Transcription Factors as Suppressors of T Lymphocyte Acute Lymphoblastic Leukemia.Frontiers in immunology · 2022Review
- Janus Kinase 3 Deficiency Promotes Vascular Reendothelialization-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Augmenting E Protein Activity Impairs cDC2 Differentiation at the Pre-cDC Stage.Frontiers in immunology · 2020Article
- Programming for T-lymphocyte fates: modularity and mechanisms.Genes & development · 2019Review
- Cytokines, Transcription Factors, and the Initiation of T-Cell Development.Cold Spring Harbor perspectives in biology · 2018Review
- Influence of maternal immunization with allergens on the thymic maturation of lymphocytes with regulatory potential in children: a broad field for further exploration.Journal of immunology research · 2014Review
- Regulation of cancer stem cells by RING finger ubiquitin ligases.Stem cell investigation · 2014Review
- Transcriptional control of early T and B cell developmental choices.Annual review of immunology · 2014Review
- Notch-regulated periphery B cell differentiation involves suppression of E protein function.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Article
- High levels of IL-7 cause dysregulation of thymocyte development.International immunology · 2012Article
- Janus kinase 3: the controller and the controlled.Acta biochimica et biophysica Sinica · 2012Review
- A mechanism underlying NOTCH-induced and ubiquitin-mediated JAK3 degradation.The Journal of biological chemistry · 2011Article
- A human thymic epithelial cell culture system for the promotion of lymphopoiesis from hematopoietic stem cells.Experimental hematology · 2011Article
- Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.Cell research · 2011Article
- Eliciting the T cell fate with Notch.Seminars in immunology · 2010Review
- Bone marrow lymphoid and myeloid progenitor cells are suppressed in 7,12-dimethylbenz(a)anthracene (DMBA) treated mice.Toxicology · 2010Article
- KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia.PLoS pathogens · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Notch signaling pathways exert diverse biological effects depending on the cellular context where Notch receptors are activated. How Notch signaling is integrated with environmental cues is a central issue. Here, we show that Notch activation accelerates ubiquitin-mediated and mitogen-activated protein kinase (MAPK)-dependent degradation of E2A transcription factors and Janus kinases, molecules essential for both B- and T-lymphocyte development. However, these events occur in B lymphocytes, but not T lymphocytes, due to their different levels of MAPK, thus providing one mechanism whereby Notch inhibits B-cell development without impairing T-cell differentiation. Lymphoid progenitors expressing a Notch-resistant E2A mutant differentiated into B-lineage cells on stromal cells expressing Notch ligands and in the thymus of transplant recipients. Bone marrow transplant assays and examination of steady-state B lymphopoiesis also revealed that the expression of Notch-resistant E2A and constitutively active STAT5 in mice neutralized the effects of Notch-induced degradation, allowing B-cell development through a bone marrow-like program in the thymus. These findings illustrate that Notch function can be influenced by MAPKs, producing distinct outcomes in different cellular contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.