ArticleInfection and immunity2008
The acute-phase reactant C-reactive protein binds to phosphorylcholine-expressing Neisseria meningitidis and increases uptake by human phagocytes.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Pathogen Evasion of Humoral Innate Immunity: Coping with C-Reactive Protein and Serum Amyloid A.International journal of molecular sciences · 2026Review
- The biosynthesis and role of phosphorylcholine in pathogenic and nonpathogenic bacteria.Trends in microbiology · 2023Review
- Article
- C-Reactive Protein Controls IL-23 Production by Human Monocytes.International journal of molecular sciences · 2021Article
- C-Reactive Protein Enhances IgG-Mediated Cellular Destruction Through IgG-Fc ReceptorsFrontiers in immunology · 2021Article
- Structure, Function, and Therapeutic Use of IgM Antibodies.Antibodies (Basel, Switzerland) · 2020Review
- Recent advances in understanding inherited deficiencies in immunity to infections.F1000Research · 2020Review
- Treatment of Pneumococcal Infection by Using Engineered Human C-Reactive Protein in a Mouse Model.Frontiers in immunology · 2020Article
- Structure-Function Relationships of C-Reactive Protein in Bacterial Infection.Frontiers in immunology · 2019Review
- Natural IgM and the Development of B Cell-Mediated Autoimmune Diseases.Critical reviews in immunology · 2016Review
- Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant.PloS one · 2015Article
- The biology of Neisseria adhesins.Biology · 2013Article
- Microbial modulation of host immunity with the small molecule phosphorylcholine.Infection and immunity · 2013Review
- Dual pili post-translational modifications synergize to mediate meningococcal adherence to platelet activating factor receptor on human airway cells.PLoS pathogens · 2013Article
- Capsular polysaccharide of Erysipelothrix rhusiopathiae, the causative agent of swine erysipelas, and its modification with phosphorylcholine.Infection and immunity · 2012Article
- Humoral innate immune response and disease.Clinical immunology (Orlando, Fla.) · 2012Review
- The role of lipooligosaccharide phosphorylcholine in colonization and pathogenesis of Histophilus somni in cattle.Veterinary research · 2012Article
- Structurally identical capsular polysaccharide expressed by intact group B streptococcus versus Streptococcus pneumoniae elicits distinct murine polysaccharide-specific IgG responses in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Opc expression, LPS immunotype switch and pilin conversion contribute to serum resistance of unencapsulated meningococci.PloS one · 2012Article
- Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neisseria meningitidis is a global cause of meningitis and septicemia. Immunity to N. meningitidis involves both innate and specific mechanisms with killing by serum bactericidal activity and phagocytic cells. C-reactive protein (CRP) is an acute-phase serum protein that has been shown to help protect the host from several bacterial pathogens, which it recognizes by binding to phosphorylcholine (PC) on their surfaces. Pathogenic Neisseria species can exhibit phase-variable PC modification on type 1 and 2 pili. We have shown that CRP can bind to piliated meningococci in a classical calcium-dependent manner. The binding of CRP to the meningococcus was concentration dependent, of low affinity, and specific for PC. CRP appears to act as an opsonin for N. meningitidis, as CRP-opsonized bacteria showed increased uptake by human macrophages and neutrophils. Further investigation into the downstream effects of CRP-bound N. meningitidis may lead us to a better understanding of meningococcal infection and help direct more effective therapeutic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.