ArticleBMC medical imaging2008
In vivo study of experimental pneumococcal meningitis using magnetic resonance imaging.
Article in BMC medical imaging, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessment of blood-brain barrier disruption using dynamic contrast-enhanced MRI. A systematic review.NeuroImage. Clinical · 2014Pooled it
- Bacterial association with metals enables in vivo monitoring of urogenital microbiota using magnetic resonance imaging.Communications biology · 2024Article
- Assessment of Blood-Brain Barrier Integrity in Tuberculous Meningitis Using Dynamic Contrast-Enhanced MR Perfusion.The Indian journal of radiology & imaging · 2021Article
- Radical Dendrimers Based on Biocompatible Oligoethylene Glycol Dendrimers as Contrast Agents for MRI.Pharmaceutics · 2020Article
- A functional observational battery for evaluation of neurological outcomes in a rat model of acute bacterial meningitis.Intensive care medicine experimental · 2020Article
- Developing a newborn rat model of ventriculitis without concomitant bacteremia by intraventricular injection of K1 (-) Escherichia coli.Pediatrics international : official journal of the Japan Pediatric Society · 2020Article
- Mesenchymal stem cells transplantation attenuates brain injury and enhances bacterial clearance in Escherichia coli meningitis in newborn rats.Pediatric research · 2018Article
- Brain ventricular dimensions and relationship to outcome in adult patients with bacterial meningitis.BMC infectious diseases · 2015Article
- Increase in hippocampal water diffusion and volume during experimental pneumococcal meningitis is aggravated by bacteremia.BMC infectious diseases · 2014Article
- Genome-wide identification of Streptococcus pneumoniae genes essential for bacterial replication during experimental meningitis.Infection and immunity · 2011Article
- Hydrocephalus induces dynamic spatiotemporal regulation of aquaporin-4 expression in the rat brain.Cerebrospinal fluid research · 2010Article
- Bacteremia causes hippocampal apoptosis in experimental pneumococcal meningitis.BMC infectious diseases · 2010Article
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Authors and funding
8 authors.
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Abstract
backgroundMagnetic Resonance Imaging (MRI) methods were evaluated as a tool for the study of experimental meningitis. The identification and characterisation of pathophysiological parameters that vary during the course of the disease could be used as markers for future studies of new treatment strategies.
methodsRats infected intracisternally with S. pneumoniae (n = 29) or saline (n = 13) were randomized for imaging at 6, 12, 24, 30, 36, 42 or 48 hours after infection. T1W, T2W, quantitative diffusion, and post contrast T1W images were acquired at 4.7 T. Dynamic MRI (dMRI) was used to evaluate blood-brain-barrier (BBB) permeability and to obtain a measure of cerebral and muscle perfusion. Clinical- and motor scores, bacterial counts in CSF and blood, and WBC counts in CSF were measured.
resultsMR images and dMRI revealed the development of a highly significant increase in BBB permeability (P < 0.002) and ventricle size (P < 0.0001) among infected rats. Clinical disease severity was closely related to ventricle expansion (P = 0.024). Changes in brain water distribution, assessed by ADC, and categorization of brain 'perfusion' by cortex DeltaSI(bolus) were subject to increased inter-rat variation as the disease progressed, but without overall differences compared to uninfected rats (P > 0.05). Areas of well-'perfused' muscle decreased with the progression of infection indicative of septicaemia (P = 0.05).
conclusionThe evolution of bacterial meningitis was successfully followed in-vivo with MRI. Increasing BBB-breakdown and ventricle size was observed in rats with meningitis whereas changes in brain water distribution were heterogeneous. MRI will be a valuable technique for future studies aiming at evaluating or optimizing adjunctive treatments.
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