ArticleJournal of cellular and molecular medicine
In vivo detection of c-Met expression in a rat C6 glioma model.
Article in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- CD73 Molecule Inhibitor Upregulates miR16 Expression in Experimental Glioblastoma and Inhibits Angiogenesis by Targeting VEGF.Journal of molecular neuroscience : MN · 2025Article
- Evaluation of [Pharmaceutics · 2023Article
- Recent progress in the imaging of c-Met aberrant cancers with positron emission tomography.Medicinal research reviews · 2022Review
- Administration of a VEGFR‑2-specific MRI contrast agent to assess orthodontic tooth movement : A pilot study.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2022Article
- In vivo Detection of Macromolecule Free Radicals in Mouse Sepsis-Associated Encephalopathy Using a New MRI and Immunospin Trapping Strategy.International journal of nanomedicine · 2022Article
- Reduction of miR-212 contributes to pituitary adenoma cell invasion via targeting c-Met.The Kaohsiung journal of medical sciences · 2020Article
- Using MRI to measure in vivo free radical production and perfusion dynamics in a mouse model of elevated oxidative stress and neurogenic atrophy.Redox biology · 2019Article
- Immuno-Spin Trapping-Based Detection of Oxidative Modifications in Cardiomyocytes and Coronary Endothelium in the Progression of Heart Failure in Tgαq*44 Mice.Frontiers in immunology · 2018Article
- Analysis of progress and challenges for various patterns of c-MET-targeted molecular imaging: a systematic review.EJNMMI research · 2017Review
- Dual Contrast - Magnetic Resonance Fingerprinting (DC-MRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast Agents.Scientific reports · 2017Article
- Quantitative Molecular Imaging with a Single Gd-Based Contrast Agent Reveals Specific Tumor Binding and Retention in Vivo.Analytical chemistry · 2017Article
- OKN-007 decreases free radical levels in a preclinical F98 rat glioma model.Free radical biology & medicine · 2015Article
- PET of c-Met in Cancer with ⁶⁴Cu-Labeled Hepatocyte Growth Factor.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2015Article
- In vivo targeted molecular magnetic resonance imaging of free radicals in diabetic cardiomyopathy within mice.Free radical research · 2015Article
- ELTD1, a potential new biomarker for gliomas.Neurosurgery · 2013Article
- Functionalized magnetic nanoparticles for the detection and quantitative analysis of cell surface antigen.BioMed research international · 2013Article
- In vivo imaging of immuno-spin trapped radicals with molecular magnetic resonance imaging in a diabetic mouse model.Diabetes · 2012Article
- Comparative analysis of protein transport in the N. benthamiana vasculature reveals different destinations.Plant signaling & behavior · 2011Article
- Molecular MRI assessment of vascular endothelial growth factor receptor-2 in rat C6 gliomas.Journal of cellular and molecular medicine · 2011Article
- Principles and basic concepts of molecular imaging.Pediatric radiology · 2011Review
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12 authors at 3 institutions in 1 country.
Funding
Abstract
The tyrosine kinase receptor, c-Met, and its substrate, the hepatocyte growth factor (HGF), are implicated in the malignant progression of glioblastomas. In vivo detection of c-Met expression may be helpful in the diagnosis of malignant tumours. The C6 rat glioma model is a widely used intracranial brain tumour model used to study gliomas experimentally. We used a magnetic resonance imaging (MRI) molecular targeting agent to specifically tag the cell surface receptor, c-Met, with an anti-c-Met antibody (Ab) linked to biotinylated Gd (gadolinium)-DTPA (diethylene triamine penta acetic acid)-albumin in rat gliomas to detect overexpression of this antigen in vivo. The anti-c-Met probe (anti-c-Met-Gd-DTPA-albumin) was administered intravenously, and as determined by an increase in MRI signal intensity and a corresponding decrease in regional T(1) relaxation values, this probe was found to detect increased expression of c-Met protein levels in C6 gliomas. In addition, specificity for the binding of the anti-c-Met contrast agent was determined by using fluorescence microscopic imaging of the biotinylated portion of the targeting agent within neoplastic and 'normal'brain tissues following in vivo administration of the anti-c-Met probe. Controls with no Ab or with a normal rat IgG attached to the contrast agent component indicated no non-specific binding to glioma tissue. This is the first successful visualization of in vivo overexpression of c-Met in gliomas.
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