ArticleJournal of cellular and molecular medicine
Interstitial Cajal-like cells in rat mesentery: an ultrastructural and immunohistochemical approach.
Article in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 81 citations in OpenAlex.
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- Primary Hepatic Extra-gastrointestinal Stromal Tumors: Molecular Pathogenesis, Immunohistopathology, and Treatment.Journal of clinical and translational hepatology · 2023Review
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- The Telocytes: Ten Years after Their Introduction in the Scientific Literature. An Update on Their Morphology, Distribution, and Potential Roles in the Gut.International journal of molecular sciences · 2020Review
- Telocytes in the Normal and Pathological Peripheral Nervous System.International journal of molecular sciences · 2020Review
- Identification of Telocytes in the Pancreas of Turtles-A role in Cellular Communication.International journal of molecular sciences · 2020Article
- Emerging diverse roles of telocytes.Development (Cambridge, England) · 2019Review
- Telocytes are the physiological counterpart of inflammatory fibroid polyps and PDGFRA-mutant GISTs.Journal of cellular and molecular medicine · 2018Article
- Telocytes and interstitial cells of Cajal in the biliary system.Journal of cellular and molecular medicine · 2018Review
- Ultrastructural and Immunohistochemical Features of Telocytes in Placental Villi in Preeclampsia.Scientific reports · 2018Article
- Uptake and intracytoplasmic storage of pigmented particles by human CD34+ stromal cells/telocytes: endocytic property of telocytes.Journal of cellular and molecular medicine · 2014Article
- Identification and characterization of telocytes in the uterus of the oviduct in the Chinese soft-shelled turtle, Pelodiscus sinensis: TEM evidence.Journal of cellular and molecular medicine · 2014Article
- Renal telocytes contribute to the repair of ischemically injured renal tubules.Journal of cellular and molecular medicine · 2014Article
- Comparative proteomic analysis of human lung telocytes with fibroblasts.Journal of cellular and molecular medicine · 2014Article
- Primary cilia in gastric gastrointestinal stromal tumours (GISTs): an ultrastructural study.Journal of cellular and molecular medicine · 2013Article
- Telocytes in neuromuscular spindles.Journal of cellular and molecular medicine · 2013Article
- Telocytes: ultrastructural, immunohistochemical and electrophysiological characteristics in human myometrium.Reproduction (Cambridge, England) · 2013Article
- Structural and ultrastructural evidence for telocytes in prostate stroma.Journal of cellular and molecular medicine · 2013Article
- Enteric neurons show a primary cilium.Journal of cellular and molecular medicine · 2013Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interstitial Cajal-like Cells (ICLC) were recently recognized in a plethora of non-digestive organs. Here, we describe a cell type of rat mesentery sharing ultrastructural and immunohistochemical features with ICLC. Mesenteric ICLC were demonstrated by transmission electron microscopy (TEM) and further tested by light microscope immunohistochemistry. The cell described here fulfils the TEM diagnostic criteria accepted for ICLC: location in the connective interstitium; close vicinity to nerves, capillaries and other interstitial cells; characteristic long, moniliform cell processes; specialized cell-to-cell junctions; caveolae; mitochondria at 5-10% of cytoplasmic volume; rough endoplasmic reticulum at about 1-2%; intermediate and thin filaments, microtubules; undetectable thick filaments. The processes of this mesenteric ICLC were particularly long, with a mean length of 24.91 microm (10.27-50.83 micorm), and a convolution index of 2.32 (1.37-3.63) was calculated in order to measure their potential length. Mean distances versus main target cells of ICLC-nerve bundles, vessels, adipocytes and macrophages-were 110.69, 115.80, 205.07 and 34.65 nm, respectively. We also tested the expression of CD117/c-kit, CD34, vimentin, alpha-smooth muscle actin, nestin, NK-1, tryptase and chymase and the antigenic profile of the mesenteric ICLC was comparable if not identical with that recently observed in ICLC from other extra-digestive tissues. Due to the peculiar aspect of the mesenteric ICLC processes it can be hypothesized that these cells form a three-dimensional network within the mesentery that is at the same time resistant and deformable following stretches consequent to intestine movements, mainly avoiding blood vessels closure or controlling blood vessels rheology. It remains, however, to be established if and how such cells are connected with the archetypal enteric ICC.
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