ArticleImmunology2008
Vdelta2 T-lymphocyte responses in cord blood samples from Italy and Côte d'Ivoire.
Article in Immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis.Nature communications · 2022Article
- Observational
- Age-related changes in PD-1 expression coincide with increased cytotoxic potential in Vδ2 T cells during infancy.Cellular immunology · 2021Article
- A Cell for the Ages: Human γδ T Cells across the Lifespan.International journal of molecular sciences · 2020Review
- Fetal public Vγ9Vδ2 T cells expand and gain potent cytotoxic functions early after birth.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Heterogeneity of Human γδ T Cells and Their Role in Cancer Immunity.Immune network · 2020Review
- Prolonged PD1 Expression on Neonatal Vδ2 Lymphocytes Dampens Proinflammatory Responses: Role of Epigenetic Regulation.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Immune responses in neonates.Expert review of clinical immunology · 2014Review
- Cord blood Vγ2Vδ2 T cells provide a molecular marker for the influence of pregnancy-associated malaria on neonatal immunity.The Journal of infectious diseases · 2014Article
- Ontogeny of Innate T Lymphocytes - Some Innate Lymphocytes are More Innate than Others.Frontiers in immunology · 2014Review
- T-cell subpopulations αβ and γδ in cord blood of very preterm infants: the influence of intrauterine infection.Archivum immunologiae et therapiae experimentalis · 2013Article
- Human cord blood γδ T cells expressing public Vγ2 chains dominate the response to bisphosphonate plus interleukin-15.Immunology · 2013Article
- Human cytomegalovirus elicits fetal gammadelta T cell responses in utero.The Journal of experimental medicine · 2010Article
- Article
- Altered cord blood gammadelta T cell repertoire in Nigeria: possible impacts of environmental factors on neonatal immunity.Molecular immunology · 2008Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cord blood T lymphocytes are immature and their functional defect partially reflects a suboptimal level of costimulatory signals provided by neonatal antigen-presenting cells. Neonatal Vdelta2 T lymphocytes, a small component of cellular immunity involved in the response against bacteria, protozoa, virus-infected cells and tumours, are also considered to be immature. Cord blood Vdelta2 T lymphocytes are mostly naïve, proliferate poorly and do not produce cytokines in response to the model phosphoantigen isopentenyl pyrophosphate. We cultured cord blood mononuclear cells with the aminobisphosphonate Pamidronate or with live bacille Calmette-Guérin, and showed that both elicit a strong cord blood Vdelta2 T-cell proliferative response, inducing the expression of activation markers and promoting the differentiation from naïve to memory cells. Our results suggest that cord blood Vdelta2 T cells are not inherently unresponsive and can mount strong responses to aminobisphosphonates and mycobacteria. Neonatal Vdelta2 T lymphocytes may be important participants in responses to microbial infections early in life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.