ArticleImmunology2008
Detrimental role of endogenous nitric oxide in host defence against Sporothrix schenckii.
Article in Immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Current Insights intoJournal of fungi (Basel, Switzerland) · 2025Article
- The Role of Macrophages in the Host's Defense againstPathogens (Basel, Switzerland) · 2021Review
- Skin Mast Cells Contribute toFrontiers in immunology · 2020Article
- Sporotrichosis In Immunocompromised Hosts.Journal of fungi (Basel, Switzerland) · 2019Review
- Endothelial nitric oxide synthase limits host immunity to control disseminated Candida albicans infections in mice.PloS one · 2019Article
- Immunity and Treatment of Sporotrichosis.Journal of fungi (Basel, Switzerland) · 2018Review
- Immunopathogenesis of Human Sporotrichosis: What We Already Know.Journal of fungi (Basel, Switzerland) · 2018Review
- An immunoproteomic approach revealing peptides from Sporothrix brasiliensis that induce a cellular immune response in subcutaneous sporotrichosis.Scientific reports · 2018Article
- Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis.PloS one · 2018Article
- Response of Cytokines and Hydrogen Peroxide to Sporothrix schenckii Exoantigen in Systemic Experimental Infection.Mycopathologia · 2016Article
- Article
- Involvement of major components from Sporothrix schenckii cell wall in the caspase-1 activation, nitric oxide and cytokines production during experimental sporotrichosis.Mycopathologia · 2015Article
- Sporothrix schenckii lymphadentitis in a male with X-linked chronic granulomatous disease.Journal of clinical immunology · 2014Article
- Article
- Sporothrix schenckii and Sporotrichosis.Clinical microbiology reviews · 2011Review
- Nitric oxide synthase activity has limited influence on the control of Coccidioides infection in mice.Microbial pathogenesis · 2011Article
- Disseminated sporotrichosis.BMJ case reports · 2011Article
- Response of macrophage Toll-like receptor 4 to a Sporothrix schenckii lipid extract during experimental sporotrichosis.Immunology · 2009Article
- Current research on the immune response to experimental sporotrichosis.Mycopathologia · 2009Review
- Fungal killing by mammalian phagocytic cells.Current opinion in microbiology · 2008Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We earlier demonstrated that nitric oxide (NO) is a fungicidal molecule against Sporothrix schenckii in vitro. In the present study we used mice deficient in inducible nitric oxide synthase (iNOS-/-) and C57BL/6 wild-type (WT) mice treated with Nomega-nitro-arginine (Nitro-Arg-treated mice), an NOS inhibitor, both defective in the production of reactive nitrogen intermediates, to investigate the role of endogenous NO during systemic sporotrichosis. When inoculated with yeast cells of S. schenckii, WT mice presented T-cell suppression and high tissue fungal dissemination, succumbing to infection. Furthermore, susceptibility of mice seems to be related to apoptosis and high interleukin-10 and tumour necrosis factor-alpha production by spleen cells. In addition, fungicidal activity and NO production by interferon-gamma (IFN-gamma) and lipopolysaccharide-activated macrophages from WT mice were abolished after fungal infection. Strikingly, iNOS-/- and Nitro-Arg-treated mice presented fungal resistance, controlling fungal load in tissues and restoring T-cell activity, as well as producing high amounts of IFN-gamma Interestingly, macrophages from these groups of mice presented fungicidal activity after in vitro stimulation with higher doses of IFN-gamma. Herein, these results suggest that although NO was an essential mediator to the in vitro killing of S. schenckii by macrophages, the activation of NO system in vivo contributes to the immunosuppression and cytokine balance during early phases of infection with S. schenckii.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.