Trial reportEuropean journal of nutrition2008
Plant sterol-enriched fermented milk enhances the attainment of LDL-cholesterol goal in hypercholesterolemic subjects.
Trial report in European journal of nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Phytosterol compositions of enriched products influence their cholesterol-lowering efficacy: a meta-analysis of randomized controlled trials.European journal of clinical nutrition · 2019Pooled it
- Role of Functional Fortified Dairy Products in Cardiometabolic Health: A Systematic Review and Meta-analyses of Randomized Clinical Trials.Advances in nutrition (Bethesda, Md.) · 2019Pooled it
- Effect of phytosterols and inulin-enriched soymilk on LDL-cholesterol in Thai subjects: a double-blinded randomized controlled trial.Lipids in health and disease · 2015Trial
- Sage tea drinking improves lipid profile and antioxidant defences in humans.International journal of molecular sciences · 2009Trial
- Cholesterol lowering effect of a soy drink enriched with plant sterols in a French population with moderate hypercholesterolemia.Lipids in health and disease · 2008Trial
- Dairy associations for the targeted control of opportunistic Candida.World journal of microbiology & biotechnology · 2021Article
- Phytosterols: From Preclinical Evidence to Potential Clinical Applications.Frontiers in pharmacology · 2020Review
- Progress and perspectives in plant sterol and plant stanol research.Nutrition reviews · 2018Review
- DNA methylation in human lipid metabolism and related diseases.Current opinion in lipidology · 2018Review
- Cholesterol Lowering Effect of Plant Stanol Ester Yoghurt Drinks with Added Camelina Oil.Cholesterol · 2016Article
- Colorimetric polymer assay for the diagnosis of plasma lipids atherogenic quality in hypercholesterolemic patients.Molecular diagnosis & therapy · 2015Article
- Inclusion of fermented foods in food guides around the world.Nutrients · 2015Review
- The food matrix and sterol characteristics affect the plasma cholesterol lowering of phytosterol/phytostanol.Advances in nutrition (Bethesda, Md.) · 2013Review
- The effect of plant sterols on serum triglyceride concentrations is dependent on baseline concentrations: a pooled analysis of 12 randomised controlled trials.European journal of nutrition · 2013Article
- Article
- Scientific Opinion on the safety of stigmasterol-rich plant sterols as food additive.EFSA journal. European Food Safety Authority · 2012Article
- Triglyceride-Lowering Response to Plant Sterol and Stanol Consumption.Journal of AOAC InternationalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe number of hypercholesterolemic individuals who do not meet their cholesterol recommended targets is inappropriately high. The use of plant sterol-enriched foods could help in this clinical setting. AIM OF THE STUDY: To evaluate the efficacy and side effects of plant sterol-enriched fermented milk in reducing LDL-cholesterol and increasing the number of patients who attain their therapeutic targets.
methodsThis was a multicentre, randomised, double-blind, placebo-controlled, parallel clinical trial. Eighty-three hypercholesterolemic patients that were not at therapeutic goals were studied. The patients received one 100 ml serving of either plain (control) low-fat or phytosterol enriched (1.6 g of free sterol equivalents) drinkable yogurt per day along with the main meal for 42 days. The principal variables were variation on LDL cholesterol (LDL-C) concentration and the number of patients achieving therapeutic goals after intervention.
resultsPatients on phytosterols attained an average LDL-C reduction of more than 10% (12.2% after 3 weeks; 10.6% after 6 weeks) (P = 0.001; 95% CI: 4.03-19.00) regardless of statin therapy compared to the control group. About 50% of the subjects on phytosterols, as compared to 20% of controls, attained their LDL-C target values (<3.3 or <2.6 mmol/l for primary and secondary prevention, respectively) at the end of the study (P < 0.001). HDL-cholesterol (HDL-C) did not change and triglycerides (TG) were decreased by 14% (P < 0.018). The plasma sterols/total cholesterol ratio increased.
conclusionsPlant sterol-enriched fermented milk significantly reduced LDL-C and increased the number of moderately hypercholesterolemic patients achieving therapeutic targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.