ReviewPflugers Archiv : European journal of physiology2008
Cellular and molecular events controlling skeletal muscle mass in response to altered use.
Review in Pflugers Archiv : European journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07036003 (Recombinant Human Growth Hormone), which is not on this map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Recombinant Human Growth Hormone (rHGH) for Knee Osteoarthritis (KORR): a Pilot, Randomized Placebo-controlled Trial
Who cites it
51 citing papers in PubMed, 146 citations in OpenAlex.
- Trial
- Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes.PloS one · 2010Trial
- Exploring the Association between Elevated Anxiety Symptoms and Low Skeletal Muscle Mass among Asymptomatic Adults: A Population-Based Study in Republic of Korea.Brain sciences · 2024Article
- Identifying lifestyle factors associated to co-morbidity of obesity and psychiatric disorders, a pilot study.Frontiers in public health · 2023Article
- Increased Carcinoembryonic Antigen (CEA) Level Is Highly Associated with Low Skeletal Muscle Mass in Asymptomatic Adults: A Population-Based Study.Journal of clinical medicine · 2022Article
- Body composition analysis components as markers for coronary artery diseases in type 2 diabetic patients.Journal of Taibah University Medical Sciences · 2022Article
- Skeletal muscle and metabolic flexibility in response to changing energy demands in wild birds.Frontiers in physiology · 2022Review
- Biomarkers in Glycogen Storage Diseases: An Update.International journal of molecular sciences · 2021Review
- Role of Sphingosine 1-Phosphate Signalling Axis in Muscle Atrophy Induced by TNFα in C2C12 Myotubes.International journal of molecular sciences · 2021Article
- Fat-to-muscle ratio is a useful index for cardiometabolic risks: A population-based observational study.PloS one · 2019Observational
- Calpain 3 and CaMKIIβ signaling are required to induce HSP70 necessary for adaptive muscle growth after atrophy.Human molecular genetics · 2018Article
- Muscle molecular adaptations to endurance exercise training are conditioned by glycogen availability: a proteomics-based analysis in the McArdle mouse model.The Journal of physiology · 2018Article
- Initiating Events in Direct Cardiomyocyte Reprogramming.Cell reports · 2018Article
- PGC-1α and PGC-1β Increase Protein Synthesis via ERRα in C2C12 Myotubes.Frontiers in physiology · 2018Article
- The involvement of transient receptor potential canonical type 1 in skeletal muscle regrowth after unloading-induced atrophy.The Journal of physiology · 2016Article
- The effect of eight weeks resistance and aerobic training on myostatin and follistatin expression in cardiac muscle of rats.Journal of cardiovascular and thoracic research · 2016Article
- Normal muscle structure, growth, development, and regeneration.Current reviews in musculoskeletal medicine · 2015Article
- The STARS signaling pathway: a key regulator of skeletal muscle function.Pflugers Archiv : European journal of physiology · 2014Review
- Mature IGF-I excels in promoting functional muscle recovery from disuse atrophy compared with pro-IGF-IA.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- GSK3β inhibition and LEF1 upregulation in skeletal muscle following a bout of downhill running.The journal of physiological sciences : JPS · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gain or loss of skeletal muscle mass occurs in situations of altered use such as strength training, aging, denervation, or immobilization. This review examines our current understanding of the cellular and molecular events involved in the control of muscle mass under conditions of muscle use and disuse, with particular attention to the effects of resistance exercise/training. The DNA content, which is a critical determinant of protein synthesis by providing the amount of DNA necessary to sustain gene transcription, can be either increased (activation of satellite cells) or decreased (apoptosis) depending on muscle activity and ongoing physiological processes. In addition, several transcription factors are sensitive to functional demand and may control muscle-specific protein expression to promote or repress myofiber enlargement. The control of skeletal muscle mass is also markedly mediated by the regulation of transduction pathways that promote the synthesis and/or the degradation of proteins. Insulin-like growth factor-I plays a key role in this balance by activating the Akt/tuberous sclerosis complex 2/mammalian target of rapamycin pathway. Stimulation of this pathway leads to the concomitant activation of initiation and elongation factors resulting in the elevation of protein translation and the downregulation of ubiquitin proteasome components through Forkhead-box O transcription factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.