ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2008
The effect of single and repeated UVB radiation on rabbit lens.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- UV light and the ocular lens: a review of exposure models and resulting biomolecular changes.Frontiers in ophthalmology · 2024Review
- A class I (Senofilcon A) soft contact lens prevents UVB-induced ocular effects, including cataract, in the rabbit in vivo.Investigative ophthalmology & visual science · 2011Article
- Metabolomic analysis of human disease and its application to the eye.Journal of ocular biology, diseases, and informatics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn our previous investigations, a significant cumulative effect of ultraviolet radiation (UVR) on the corneal and aqueous humour metabolic profiles was revealed. The purpose of the present study was to monitor the alterations in the rabbit lenses under the same experimental design and thereby supplement and complete prior findings.
methodsAlbino rabbit eyes were exposed to single (312 nm, 3.12 J/cm2) or repeated (312 nm, 3 x 1.04 J/cm2) UVB irradiations of the same overall doses. Lenticular samples were analysed by high resolution magic angle spinning proton nuclear magnetic resonance (HR-MAS 1H NMR) spectroscopy. Special grouping patterns between the UVB-irradiated and untreated control samples were evaluated using principal component analysis (PCA). Percentage alterations in the lenticular metabolite concentrations from UVR-B exposed rabbits were calculated relative to the levels in the control group.
resultsUVB irradiation of the albino rabbit lenses resulted in a significant decrease in the concentrations of antioxidants (glutathione), osmolytes (taurine, myoinositol) and amino acids (alanine), and a concomitant elevation in the contents of a sugar-related compound, sorbitol. Repeated UVR-B exposure of the rabbit eye had a stronger effect on the lenticular metabolic profile than a single irradiation of the same overall dose.
conclusionsThis study reveals the cumulative effect of repeated UVB irradiations, and shows that even a 48-hour interval between subsequent UVR-B exposures is not sufficient for the healing processes to restore lenticular integrity.
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Registered trials
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