ArticleJournal of neural transmission (Vienna, Austria : 1996)2008
Neuroleptics and animal models: feasibility of oral treatment monitored by plasma levels and receptor occupancy assays.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Continuous oral olanzapine or clozapine treatment initiated in adolescence has differential short- and long-term impacts on antipsychotic sensitivity than those initiated in adulthood.European journal of pharmacology · 2024Article
- Reversal of social deficits by subchronic oxytocin in two autism mouse models.Neuropharmacology · 2016Article
- Dopamine denervation of the prefrontal cortex increases expression of the astrocytic glutamate transporter GLT-1.Journal of neurochemistry · 2014Article
- Assessment of cytochrome C oxidase dysfunction in the substantia nigra/ventral tegmental area in schizophrenia.PloS one · 2014Article
- Olanzapine treatment of adolescent rats alters adult reward behaviour and nucleus accumbens function.The international journal of neuropsychopharmacology · 2013Article
- Olanzapine treatment of adolescent rats causes enduring specific memory impairments and alters cortical development and function.PloS one · 2013Article
- Dopamine pathology in schizophrenia: analysis of total and phosphorylated tyrosine hydroxylase in the substantia nigra.Frontiers in psychiatry · 2012Article
- Phencyclidine-induced loss of asymmetric spine synapses in rodent prefrontal cortex is reversed by acute and chronic treatment with olanzapine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Long term antipsychotic treatment does not alter metabolite concentrations in rat striatum: an in vivo magnetic resonance spectroscopy study.Schizophrenia research · 2011Article
- Evaluating early preventive antipsychotic and antidepressant drug treatment in an infection-based neurodevelopmental mouse model of schizophrenia.Schizophrenia bulletin · 2010Article
- Dystrophic dendrites in prefrontal cortical pyramidal cells of dopamine D1 and D2 but not D4 receptor knockout mice.Brain research · 2009Article
- A role for dopamine D2 receptors in reversal learning.Neuroscience · 2009Article
- Dopamine depletion of the prefrontal cortex induces dendritic spine loss: reversal by atypical antipsychotic drug treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008Article
- Neuroleptics and animal models: feasibility of oral treatment monitored by plasma levels and receptor occupancy assays.Journal of neural transmission (Vienna, Austria : 1996) · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The administration of neuroleptics in animal models has been extensively reported and plays an important role in the study of schizophrenia. Our study was designed to address the following questions: (1) Is it possible to achieve steady-state receptor occupancy levels administering neuroleptics in drinking water? (2) Is there an appropriate dose to obtain clinically comparable receptor occupancies? (3) Is there a correlation between plasma drug levels and receptor occupancy? Thus, we tested three neuroleptic drugs administered in drinking water for 7 days. Plasma drug levels were measured, and in vivo receptor occupancy assays were performed in order to determine peak and trough dopamine D(2) receptor occupancies in striatal brain samples. Overall, our study indicates that in rodents the administration of appropriate doses of haloperidol and olanzapine in drinking water achieves receptor occupancies comparable to the clinical occupancy levels, but this appears not to be the case for clozapine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.