SynthesisNature genetics2008
Common variants in the GDF5-UQCC region are associated with variation in human height.
Synthesis in Nature genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 220 papers, 20 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
220 citing papers in PubMed, 20 syntheses or guidelines pooled it, 401 citations in OpenAlex.
- A meta-analysis of genome-wide association studies to identify candidate genes associated with feed efficiency traits in pigs.Journal of animal science · 2025Pooled it
- Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women.Nature communications · 2021Pooled it
- Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability.Molecular psychiatry · 2018Pooled it
- Taller height as a risk factor for venous thromboembolism: a Mendelian randomization meta-analysis.Journal of thrombosis and haemostasis : JTH · 2017Pooled it
- Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization.Journal of the National Cancer Institute · 2015Pooled it
- Pooled it
- Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci.PloS one · 2014Pooled it
- Genetics of serum BDNF: meta-analysis of the Val66Met and genome-wide association study.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2013Pooled it
- Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error.Human molecular genetics · 2013Pooled it
- Genome-wide association study in Han Chinese identifies three novel loci for human height.Human genetics · 2013Pooled it
- Rs143383 in the growth differentiation factor 5 (GDF5) gene significantly associated with osteoarthritis (OA)-a comprehensive meta-analysis.International journal of medical sciences · 2013Pooled it
- CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results.Addiction (Abingdon, England) · 2012Pooled it
- Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe).Human molecular genetics · 2012Pooled it
- Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.PLoS genetics · 2011Pooled it
- Pooled it
- GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women.Arthritis and rheumatism · 2011Pooled it
- Genome-wide association scan of trait depression.Biological psychiatry · 2010Pooled it
- Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs.Human molecular genetics · 2009Pooled it
- Genomewide association study for onset age in Parkinson disease.BMC medical genetics · 2009Pooled it
- Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.PLoS genetics · 2009Pooled it
160 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors at 15 institutions in 4 countries.
Funding
Abstract
Identifying genetic variants that influence human height will advance our understanding of skeletal growth and development. Several rare genetic variants have been convincingly and reproducibly associated with height in mendelian syndromes, and common variants in the transcription factor gene HMGA2 are associated with variation in height in the general population. Here we report genome-wide association analyses, using genotyped and imputed markers, of 6,669 individuals from Finland and Sardinia, and follow-up analyses in an additional 28,801 individuals. We show that common variants in the osteoarthritis-associated locus GDF5-UQCC contribute to variation in height with an estimated additive effect of 0.44 cm (overall P < 10(-15)). Our results indicate that there may be a link between the genetic basis of height and osteoarthritis, potentially mediated through alterations in bone growth and development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.