ArticleRNA (New York, N.Y.)2008
Translational activation by the noncoding RNA DsrA involves alternative RNase III processing in the rpoS 5'-leader.
Article in RNA (New York, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Selective RNA Processing and Stabilization are Multi-Layer and Stoichiometric Regulators of Gene Expression in Escherichia coli.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Key players in regulatory RNA realm of bacteria.Biochemistry and biophysics reports · 2022Review
- RNase III Participates in the Adaptation to Temperature Shock and Oxidative Stress inMicroorganisms · 2022Article
- Article
- Transcript decay mediated by RNase III in Borrelia burgdorferi.Biochemical and biophysical research communications · 2020Article
- Mechanisms for Hfq-Independent Activation ofMolecules and cells · 2019Article
- RNase III Processing of rRNA in the Lyme Disease Spirochete Borrelia burgdorferi.Journal of bacteriology · 2018Article
- Genome-wide mRNA processing in methanogenic archaea reveals post-transcriptional regulation of ribosomal protein synthesis.Nucleic acids research · 2017Article
- Target activation by regulatory RNAs in bacteria.FEMS microbiology reviews · 2015Review
- Clostridium difficile Hfq can replace Escherichia coli Hfq for most of its function.RNA (New York, N.Y.) · 2014Article
- Functional conservation of RNase III-like enzymes: studies on a Vibrio vulnificus ortholog of Escherichia coli RNase III.Current microbiology · 2014Article
- Article
- Small RNAs in the control of RpoS, CsgD, and biofilm architecture of Escherichia coli.RNA biology · 2014Review
- Duplex formation between the sRNA DsrA and rpoS mRNA is not sufficient for efficient RpoS synthesis at low temperature.RNA biology · 2013Article
- Escherichia coli YmdB regulates biofilm formation independently of its role as an RNase III modulator.BMC microbiology · 2013Article
- The virulence of Salmonella enterica Serovar Typhimurium in the insect model galleria mellonella is impaired by mutations in RNase E and RNase III.Applied and environmental microbiology · 2013Article
- Antisense regulation by transposon-derived RNAs in the hyperthermophilic archaeon Sulfolobus solfataricus.EMBO reports · 2013Article
- Structural flexibility of RNA as molecular basis for Hfq chaperone function.Nucleic acids research · 2012Article
- Analysis of Escherichia coli RNase E and RNase III activity in vivo using tiling microarrays.Nucleic acids research · 2011Article
- Accessibility and evolutionary conservation mark bacterial small-rna target-binding regions.Journal of bacteriology · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The intricate regulation of the Escherichia coli rpoS gene, which encodes the stationary phase sigma-factor sigmaS, includes translational activation by the noncoding RNA DsrA. We observed that the stability of rpoS mRNA, and concomitantly the concentration of sigmaS, were significantly higher in an RNase III-deficient mutant. As no decay intermediates corresponding to the in vitro mapped RNase III cleavage site in the rpoS leader could be detected in vivo, the initial RNase III cleavage appears to be decisive for the observed rapid inactivation of rpoS mRNA. In contrast, we show that base-pairing of DsrA with the rpoS leader creates an alternative RNase III cleavage site within the rpoS/DsrA duplex. This study provides new insights into regulation by small regulatory RNAs in that the molecular function of DsrA not only facilitates ribosome loading on rpoS mRNA, but additionally involves an alternative processing of the target.
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