ArticleBiophysical journal2008
Ejection dynamics of polymeric chains from viral capsids: effect of solvent quality.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Role of DNA-DNA sliding friction and nonequilibrium dynamics in viral genome ejection and packaging.Nucleic acids research · 2023Article
- Article
- The Semiflexible Polymer Translocation into Laterally Unbounded Region between Two Parallel Flat Membranes.Polymers · 2016Article
- Computational virology: From the inside out.Biochimica et biophysica acta · 2016Review
- Effects of pulling forces, osmotic pressure, condensing agents and viscosity on the thermodynamics and kinetics of DNA ejection from bacteriophages to bacterial cells: a computational study.Journal of physics. Condensed matter : an Institute of Physics journal · 2013Article
- Langevin dynamics simulation of DNA ejection from a phage.Journal of biological physics · 2013Article
- Article
- Is the in vitro ejection of bacteriophage DNA quasistatic? A bulk to single virus study.Biophysical journal · 2010Article
- Simulations of knotting in confined circular DNA.Biophysical journal · 2008Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present simulations investigating the effects of solvent quality on the dynamics of flexible (RNA-like) and semiflexible (DNA-like) polymers ejecting from spherical viral capsids. We find that the mean ejection time increases and the ejection time distributions are broadened as the solvent quality decreases. Our results thus suggest that DNA ejection may be very efficiently controlled by tuning the salt concentration in the environment, in agreement with recent experimental findings. We also observe random pauses in the ejection. These become extremely long for semiflexible polymers at lower solvent quality, and we interpret this as a signature of a low driving force for ejection. We find that, for most polymers, ejection is an all-or-nothing process at the solvent conditions we investigated: polymers normally completely eject once the process is initiated.
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Registered trials
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