ArticleBiophysical journal2008
Mechanosensitive membrane channels in action.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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Who cites it
43 citing papers in PubMed.
- Article
- Asymmetric Nature of MscL Opening Revealed by Molecular Dynamics Simulations.Journal of chemical information and modeling · 2025Article
- Bragg-Williams Theory for Particles with a Size-Modulating Internal Degree of Freedom.Molecules (Basel, Switzerland) · 2023Article
- Computational studies of Piezo1 yield insights into key lipid-protein interactions, channel activation, and agonist binding.Biophysical reviews · 2022Review
- Mechanical Activation of MscL Revealed by a Locally Distributed Tension Molecular Dynamics Approach.Biophysical journal · 2021Article
- A Novel Approach to Simulating the Gating Transitions of Mechanosensitive Channels.Biophysical journal · 2021Article
- Ion Channels in Biophysics and Physiology: Methods & Challenges to Study Mechanosensitive Ion Channels.Advances in experimental medicine and biology · 2021Article
- High-Throughput Simulations Reveal Membrane-Mediated Effects of Alcohols on MscL Gating.Journal of the American Chemical Society · 2017Article
- Inducible release of particulates from liposomes using the mechanosensitive channel of large conductance and L-α-lysophosphatidylcholine.European biophysics journal : EBJ · 2015Article
- Mechanotransduction Mechanisms for Intraventricular Diastolic Vortex Forces and Myocardial Deformations: Part 2.Journal of cardiovascular translational research · 2015Article
- Breaking the hydrophobicity of the MscL pore: insights into a charge-induced gating mechanism.PloS one · 2015Article
- Global structural changes of an ion channel during its gating are followed by ion mobility mass spectrometry.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The activation mode of the mechanosensitive ion channel, MscL, by lysophosphatidylcholine differs from tension-induced gating.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- The power of coarse graining in biomolecular simulations.Wiley interdisciplinary reviews. Computational molecular science · 2014Article
- The effect of local bending on gating of MscL using a representative volume element and finite element simulation.Channels (Austin, Tex.) · 2014Article
- Conformational flexibility of the leucine binding protein examined by protein domain coarse-grained molecular dynamics.Journal of molecular modeling · 2013Article
- PRIMO: A Transferable Coarse-grained Force Field for Proteins.Journal of chemical theory and computation · 2013Article
- Modeling and simulation of ion channels.Chemical reviews · 2012Review
- Use of X-ray scattering to aid the design and delivery of membrane-active drugs.European biophysics journal : EBJ · 2012Review
- Molecular dynamics simulations of creatine kinase and adenine nucleotide translocase in mitochondrial membrane patch.The Journal of biological chemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tension-driven gating process of MscL from Mycobacterium tuberculosis, Tb-MscL, has been addressed at near-atomic detail using coarse-grained molecular dynamics simulations. To perform the simulations, a novel coarse-grained peptide model based on a thermodynamic parameterization of the amino-acid side chains has been applied. Both the wild-type Tb-MscL and its gain-of-function mutant V21D embedded in a solvated lipid bilayer have been studied. To mimic hypoosmotic shock conditions, simulations were performed at increasing levels of membrane tension approaching the rupture threshold of the lipid bilayer. Both the wild-type and the mutant channel are found to undergo significant conformational changes in accordance with an irislike expansion mechanism, reaching a conducting state on a microsecond timescale. The most pronounced expansion of the pore has been observed for the V21D mutant, which is consistent with the experimentally shown gain-of-function phenotype of the V21D mutant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.