ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2008
A large scale analysis of protein-protein interactions in the nitrogen-fixing bacterium Mesorhizobium loti.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 79 citations in OpenAlex.
- The protein interactome of the citrus Huanglongbing pathogen Candidatus Liberibacter asiaticus.Nature communications · 2023Article
- Computational Network Inference for Bacterial Interactomics.mSystems · 2022Review
- Computationally Reconstructed Interactome ofInternational journal of molecular sciences · 2021Article
- Structure-Function Analysis of Interallelic Complementation inPlant physiology · 2020Article
- Characterization of the Sinorhizobium meliloti HslUV and ClpXP Protease Systems in Free-Living and Symbiotic States.Journal of bacteriology · 2019Article
- Proteome Data Improves Protein Function Prediction in the Interactome ofMolecular & cellular proteomics : MCP · 2018Article
- Protein-protein interactions in bacteria: a promising and challenging avenue towards the discovery of new antibiotics.Beilstein journal of organic chemistry · 2018Review
- Bacterial protein meta-interactomes predict cross-species interactions and protein function.BMC bioinformatics · 2017Article
- Cell-free Determination of Binary Complexes That Comprise Extended Protein-Protein Interaction Networks of Yersinia pestis.Molecular & cellular proteomics : MCP · 2016Article
- The interactome of Streptococcus pneumoniae and its bacteriophages show highly specific patterns of interactions among bacteria and their phages.Scientific reports · 2016Article
- Genome-wide prediction of prokaryotic two-component system networks using a sequence-based meta-predictor.BMC bioinformatics · 2015Article
- Quantifying noise in mass spectrometry and yeast two-hybrid protein interaction detection experiments.Journal of the Royal Society, Interface · 2015Article
- Bacterial protein networks: properties and functions.Nature reviews. Microbiology · 2015Review
- A putative bifunctional histidine kinase/phosphatase of the HWE family exerts positive and negative control on the Sinorhizobium meliloti general stress response.Journal of bacteriology · 2014Article
- A second-generation protein-protein interaction network of Helicobacter pylori.Molecular & cellular proteomics : MCP · 2014Article
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- Building a hierarchical organization of protein complexes out of protein association data.PloS one · 2014Article
- CyanoBase and RhizoBase: databases of manually curated annotations for cyanobacterial and rhizobial genomes.Nucleic acids research · 2014Article
- Corbi: a new R package for biological network alignment and querying.BMC systems biology · 2013Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Global viewing of protein-protein interactions (PPIs) is a useful way to assign biological roles to large numbers of proteins predicted by complete genome sequence. Here, we systematically analyzed PPIs in the nitrogen-fixing soil bacterium Mesorhizobium loti using a modified high-throughput yeast two-hybrid system. The aims of this study are primarily on the providing functional clues to M. loti proteins that are relevant to symbiotic nitrogen fixation and conserved in other rhizobium species, especially proteins with regulatory functions and unannotated proteins. By the screening of 1542 genes as bait, 3121 independent interactions involving 1804 proteins (24% of the total protein coding genes) were identified and each interaction was evaluated using an interaction generality (IG) measure and the general features of the interacting partners. Most PPIs detected in this study are novel interactions revealing potential functional relationships between genes for symbiotic nitrogen fixation and signal transduction. Furthermore, we have predicted the putative functions of unannotated proteins through their interactions with known proteins. The results described here represent new insight into protein network of M. loti and provide useful experimental clues to elucidate the biological function of rhizobial genes that can not be assigned directly from their genomic sequence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.