ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2008
The animal in the genome: comparative genomics and evolution.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Deciphering a shared transcriptomic regulation and the relative contribution of each regulator type through endometrial gene expression signatures.Reproductive biology and endocrinology : RB&E · 2023Article
- Diversification and Functional Evolution of HOX Proteins.Frontiers in cell and developmental biology · 2022Review
- Multivariate analysis of genomic variables, effective population size, and mutation rate.BMC research notes · 2019Article
- Perspectives on the history of evo-devo and the contemporary research landscape in the genomics era.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- The Unicellular Ancestry of Groucho-Mediated Repression and the Origins of Metazoan Transcription Factors.Genome biology and evolution · 2016Article
- The relationship between gene isoform multiplicity, number of exons and protein divergence.PloS one · 2013Article
- Ancestral and conserved cis-regulatory architectures in developmental control genes.Developmental biology · 2012Article
- Correlating traits of gene retention, sequence divergence, duplicability and essentiality in vertebrates, arthropods, and fungi.Genome biology and evolution · 2011Article
- Alzheimer's disease: insights from Drosophila melanogaster models.Trends in biochemical sciences · 2010Review
- Evidence of uneven selective pressure on different subsets of the conserved human genome; implications for the significance of intronic and intergenic DNA.BMC genomics · 2009Article
- Early origin of the bilaterian developmental toolkit.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Article
- Functional and comparative genomics analyses of pmp22 in medaka fish.BMC neuroscience · 2009Article
- Apprehending multicellularity: regulatory networks, genomics, and evolution.Birth defects research. Part C, Embryo today : reviews · 2009Review
- Comparative functional analysis of the Caenorhabditis elegans and Drosophila melanogaster proteomes.PLoS biology · 2009Article
- Estimating the size of the human interactome.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- The evolution of the animals: introduction to a Linnean tercentenary celebration.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2008Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Comparisons between completely sequenced metazoan genomes have generally emphasized how similar their encoded protein content is, even when the comparison is between phyla. Given the manifest differences between phyla and, in particular, intuitive notions that some animals are more complex than others, this creates something of a paradox. Simplistic explanations have included arguments such as increased numbers of genes; greater numbers of protein products produced through alternative splicing; increased numbers of regulatory non-coding RNAs and increased complexity of the cis-regulatory code. An obvious value of complete genome sequences lies in their ability to provide us with inventories of such components. I examine progress being made in linking genome content to the pattern of animal evolution, and argue that the gap between genomic and phenotypic complexity can only be understood through the totality of interacting components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.