ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2008
The evolution of nervous system centralization.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed, 197 citations in OpenAlex.
- Ancient Somatosensory Circuit Architectures Employ Flexible Molecular Strategies.bioRxiv : the preprint server for biology · 2026Article
- Research progress on the Sonic Hedgehog signaling pathway in the central nervous system: Novel insights.Neural regeneration research · 2026Article
- The anti-neural role of BMP signaling is a consequence of its ancestral function in dorsoventral patterning.PLoS biology · 2026Article
- Evidence of autonomous neural specification for both brain and ventral nerve cord tissue in Annelida.bioRxiv : the preprint server for biology · 2026Article
- Early nervous system development in the chaetognathFrontiers in cell and developmental biology · 2026Article
- The ancient dialogue between brain and body.Current biology : CB · 2025Article
- Interactions between CNS regulation and serotonergic modulation of crayfish hindgut motility.Royal Society open science · 2025Article
- Brain-associated alterations of Hippo pathway transcription in early maturing Atlantic salmon.BMC ecology and evolution · 2025Article
- Unfolding the ventral nerve center of chaetognaths.Neural development · 2024Article
- On growth and form of animal behavior.Frontiers in integrative neuroscience · 2024Article
- Review
- Hemichordates' diffuse "skin brain" shows unexpected complexity.PLoS biology · 2023Article
- Editorial: Methods and applications in invertebrate physiology.Frontiers in physiology · 2023Article
- Homologous gene regulatory networks control development of apical organs and brains in Bilateria.Science advances · 2022Article
- Insights into nervous system repair from the fruit fly.Neuronal signaling · 2022Review
- Paligenosis: Cellular Remodeling During Tissue Repair.Annual review of physiology · 2022Review
- Humans, fish, spiders and bees inherited working memory and attention from their last common ancestor.Frontiers in psychology · 2022Article
- Article
- Review
- Neural architecture and regeneration in the acoelProceedings. Biological sciences · 2020Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is yet unknown when and in what form the central nervous system in Bilateria first came into place and how it further evolved in the different bilaterian phyla. To find out, a series of recent molecular studies have compared neurodevelopment in slow-evolving deuterostome and protostome invertebrates, such as the enteropneust hemichordate Saccoglossus and the polychaete annelid Platynereis. These studies focus on the spatially different activation and, when accessible, function of genes that set up the molecular anatomy of the neuroectoderm and specify neuron types that emerge from distinct molecular coordinates. Complex similarities are detected, which reveal aspects of neurodevelopment that most likely occurred already in a similar manner in the last common ancestor of the bilaterians, Urbilateria. This way, different aspects of the molecular architecture of the urbilaterian nervous system are reconstructed and yield insight into the degree of centralization that was in place in the bilaterian ancestors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.