ArticleBiomaterials2008
The biodegradability of electrospun Dextran/PLGA scaffold in a fibroblast/macrophage co-culture.
Article in Biomaterials, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 65 citations in OpenAlex.
- Microstructural Analysis of the Human Scapula: Mandibular Bone Tissue Engineering Perspectives.Journal of functional biomaterials · 2024Article
- Tunable Physical Properties of Electro-Blown Spinning Dextran/Zein Nanofibers Cross-Linked by Maillard Reaction.Foods (Basel, Switzerland) · 2024Article
- Dynamic degradation patterns of porous polycaprolactone/β-tricalcium phosphate composites orchestrate macrophage responses and immunoregulatory bone regeneration.Bioactive materials · 2023Article
- Review
- Drug Eluting Embolization Particles for Permanent Contraception.ACS biomaterials science & engineering · 2022Article
- Article
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- Biomaterials for Skin Substitutes.Advanced healthcare materials · 2018Review
- Biodegradation and biocompatibility of a degradable chitosan vascular prosthesis.International journal of clinical and experimental medicine · 2015Article
- Injectable dopamine-modified poly(ethylene glycol) nanocomposite hydrogel with enhanced adhesive property and bioactivity.ACS applied materials & interfaces · 2014Article
- Contribution of fibroblasts to the mechanical stability of in vitro engineered dermal-like tissue through extracellular matrix deposition.BioResearch open access · 2014Article
- Matricellular proteins and biomaterials.Matrix biology : journal of the International Society for Matrix Biology · 2014Review
- Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity.Nature communications · 2014Article
- Viscoelasticity of repaired sciatic nerve by poly(lactic-co-glycolic acid) tubes.Neural regeneration research · 2013Article
- Poly(lactic-co-glycolic acid) conduit for repair of injured sciatic nerve: A mechanical analysis.Neural regeneration research · 2013Article
- Biodegradability and biocompatibility study of poly(chitosan-g-lactic acid) scaffolds.Molecules (Basel, Switzerland) · 2012Article
- The functional behavior of a macrophage/fibroblast co-culture model derived from normal and diabetic mice with a marine gelatin-oxidized alginate hydrogel.Biomaterials · 2010Article
- Localized immunosuppressive environment in the foreign body response to implanted biomaterials.The American journal of pathology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Fibroblast and macrophage are 2 dominant cell types respond cooperatively to degrade implanted biomaterials. Using an electrospun Dextran/Poly-lactide-co-glycolide (PLGA) scaffold as a model, an in vitro fibroblast/macrophage co-culture system was developed to investigate the degradability of implantable biodegradable materials. SEM showed that both fibroblasts and macrophages were able to degrade the scaffold, separately or cooperatively. Under the synergistic coordination of macrophages and fibroblasts, scaffolds showed faster degradation rate than their counterparts incubated with a single type of cells as well as in PBS or cell culture medium. Lysozyme, non-specific esterase (NSE), gelatinase, hyaluronidase-1 and alpha-glucosidase were up-regulated in the presence of the scaffold, suggesting their roles in the cell-mediated scaffold degradation. In addition, the expressions of cell surface receptors CD204 and Toll like receptor 4 (TLR4) were elevated 1 week after cell seeding, implying that these receptors might be involved in scaffold degradation. The results of in vivo subdermal implantation of the scaffold further confirmed the biodegradability of the Dextran/PLGA scaffold. The fibroblast/macrophage co-culture model adequately mimicked the in vivo environment and could be further developed into an in vitro tool for initial biomaterial evaluation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.